Corneal infection

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This study tests whether adding cyclosporine A eye drops to standard natamycin treatment helps people with fungal keratitis (a serious eye infection). About 150 adults with confirmed fungal infection will receive either a low or high dose of cyclosporine A or a placebo for 4 week…

This Phase 3 trial tests whether adding steroid eye drops to standard anti-parasitic treatment improves vision in people with acanthamoeba keratitis, a rare but serious eye infection. About 232 participants who still have eye inflammation after one month of standard care will rec…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests whether injecting the antibiotic moxifloxacin directly into the cornea can help treat bacterial eye infections that don't improve with standard antibiotic drops. About 60 adults with stubborn corneal infections will receive either the injection plus drops or drop…

This study tests whether injecting anti-VEGF medication directly into the cornea can safely reduce abnormal blood vessel growth caused by herpes simplex keratitis. One hundred adults will receive either the injection plus antiviral eye drops or standard antiviral drops alone. Res…

This study is testing advanced lab techniques, like genetic sequencing and multiplex PCR, to improve how doctors diagnose complex eye infections such as endophthalmitis and severe corneal abscesses. Researchers will compare the new methods to standard cultures to see if they find…

This long-term study collects data from over 100 eye clinics in Germany to see how corneal transplant surgeries have changed since 2001. Researchers track the number of surgeries, the types of procedures used, and the reasons people need them. The goal is to understand trends, no…

This study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …