Could steroids save sight in parasitic eye disease?
NCT ID NCT06213649
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether adding steroid eye drops to standard anti-parasitic treatment improves vision in people with acanthamoeba keratitis, a rare but serious eye infection. About 232 participants who still have eye inflammation after one month of standard care will receive either steroid drops or placebo drops for several weeks. The main goal is to see if steroids help achieve better vision and reduce pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
topical corticosteroid (dexamethasone)
What this could lead to
If successful, adding steroids could reduce inflammation and improve vision outcomes for people with this rare eye infection.
What could go wrong
This is a Phase 3 trial, but it only includes people who still have inflammation after 4 weeks of standard treatment. Steroids may also suppress the immune response, potentially worsening the infection.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Aravind Eye Hospital
RECRUITINGCoimbatore, Tamil Nadu, India
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Aravind Eye Hospital
RECRUITINGMadurai, Tamil Nadu, India
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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Federal University of São Paulo
RECRUITINGSão Paulo, Brazil
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21287, United States
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Moorfields Eye Hospital
RECRUITINGLondon, United Kingdom
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94158, United States
Contact
Contact
Contact Email: •••••@•••••
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University of Colorado Anschutz
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida
RECRUITINGGainesville, Florida, 32605, United States
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University of Illinois, Chicago
RECRUITINGChicago, Illinois, 60612, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15219, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington
RECRUITINGSeattle, Washington, 98104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••