Corneal disorder

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This early-stage study is testing whether a specially prepared membrane made from donated human tissue can help heal chronic wounds, like diabetic foot ulcers and eye surface injuries. The membrane is sterilized with different doses of radiation to find the best balance between s…

This registry collects long-term data from hundreds of people in Germany who have undergone corneal cross linking for keratoconus, a condition where the cornea thins and bulges, causing vision loss. The procedure uses riboflavin (vitamin B2) eye drops and UV light to stiffen the …

This study looks at a rare disease called KSHV-associated multicentric Castleman's disease (MCD), caused by a virus. Researchers are testing several drug combinations, including chemotherapy and antivirals, to see if they can control the disease. The study also tracks how the dis…

This phase 3 trial tests a procedure called corneal collagen crosslinking for people with progressive keratoconus, a condition where the cornea thins and bulges, blurring vision. The treatment uses riboflavin (vitamin B2) drops and UV light to stiffen the cornea. The study aims t…

This study compares two types of corneal transplant surgery (UT-DSAEK and DMEK) in 160 people with Fuchs dystrophy, a condition that clouds the cornea. It also tests whether a drug called rho-kinase inhibitor can reduce loss of important eye cells after surgery. The goal is to fi…

This early-stage trial tests whether injecting cultured corneal endothelial cells into the eye can repair damaged corneas and improve vision. Twelve adults with corneal swelling and poor eyesight received a single injection of donor cells grown in a lab. The goal is to see if the…

This study tests whether using two eye drops together—Vevye (cyclosporine) and Flarex (a steroid)—can safely improve symptoms in adults with moderate to severe dry eye disease. Sixty participants will use Vevye twice daily and Flarex four times daily for one month. The goal is to…

This study tests whether a new surgical guide (the Alfonso nomogram) helps doctors place corneal ring implants more effectively in people with moderate keratoconus. Twenty-five adults aged 18–35 with progressive disease received the implant. Researchers will measure changes in vi…

This study tests whether a tiny steroid-releasing implant (Dextenza) placed in the tear duct works as well as standard steroid eye drops after corneal crosslinking surgery for keratoconus. About 20 people aged 13 and older with progressive keratoconus will receive either the impl…

This Phase 2 trial tests whether sibeprenlimab, a biologic drug given as a shot every 4 weeks, can reduce disease activity and symptoms in people with Sjögren's disease. About 83 adults with moderate-to-active disease will receive either the drug or a placebo, added to their usua…

This phase 2 study tests the drug sirolimus (rapamycin) in 7 people with idiopathic multicentric Castleman disease who have not improved with standard therapy. The goal is to see if sirolimus can improve symptoms like fatigue, fever, and night sweats, and shrink enlarged lymph no…

This early-stage study tests whether stem cells grown from a patient's own eye can be safely transplanted to repair the cornea in people with limbal stem cell deficiency, a condition that causes vision loss. Twenty adults with severe vision loss will receive the transplant, and r…

This early study tests whether TN-001 eye drops are safe and can stop keratoconus, a disease that thins and bulges the cornea, from getting worse. About 20 adults with progressive keratoconus will use the drops twice daily for 3-6 weeks. Researchers will monitor for side effects …

This study tests whether a light-activated dye called rose Bengal, combined with antibiotics and steroids, can improve vision in people with severe bacterial eye infections. About 60 adults with corneal ulcers and vision loss will receive either the dye treatment or a sham proced…

This study was designed to check the long-term safety of a new eye drop that combines two active ingredients (lifitegrast and perfluorohexyloctane) for people with dry eye disease. It was a follow-up for people who had already completed an earlier study. However, the trial was wi…

This study looks at how removing a pterygium (a fleshy growth on the eye) and replacing it with a small piece of the patient's own eye tissue changes the shape of the cornea. Researchers will measure the cornea's curve before and one month after surgery in 130 adults aged 30 to 7…

This Phase 3 trial tests CBT-001 eye drops against a placebo in 660 people with pterygium, a non-cancerous growth on the eye's surface. The goal is to see if the drops can reduce redness and stop the growth from getting bigger over 24 months. If successful, it could offer a drug-…

This study compares using cyclosporine eye drops alone versus combining them with absorbable punctal plugs for dry eye caused by Sjögren's syndrome. Thirty participants will receive the drops in both eyes and a plug in one eye to see if the combination improves symptoms better. T…

This phase II trial tests the drug rituximab (Rituxan) as a first treatment for multicentric Castleman disease, a rare immune disorder, in 15 adults in Malawi. Some high-risk patients also receive etoposide. The study aims to see if rituximab is safe and works better than standar…

This study aimed to see if a soft membrane placed on the eye could diagnose microbial keratitis (a serious eye infection) better and more comfortably than the standard scrape test. Researchers planned to compare the two methods in adults with new corneal infections. However, the …

This study compares a new AI system, called AEYE, against a human eye doctor in diagnosing keratoconus and deciding who is eligible for laser vision correction. The AI analyzes patient history, eye scans, and other data to make its recommendations. Researchers will check if the A…

This study tests a new artificial tear called ABBV-444 against an existing brand, Refresh Optive, in 250 adults with dry eye disease. Participants use the assigned eye drops for 90 days. The goal is to see if the new formula improves eye comfort and surface health better than the…

This study aimed to see if a saffron-based supplement called AffronEye® could improve dry eye symptoms in university staff and students. It planned to compare the supplement to a placebo over 84 days using eye tests and symptom questionnaires. However, the study was withdrawn bef…

This early-phase trial tests whether eye drops made from mesenchymal stem cells can safely relieve symptoms in 10 women aged 40-60 with dry eye disease that didn't improve with artificial tears. Participants use the drops twice daily for two weeks and are followed for three month…

This study tests whether an oral supplement that targets gut bacteria can improve dry eye symptoms in adults with moderate evaporative dry eye disease. Over 8 weeks, 130 participants will take either the supplement or a placebo. The main goal is to see if symptoms, measured by a …

This study tests a low-level light therapy mask for dry eye disease in people with Graves' eye disease who haven't improved with standard treatments. Thirty adults will receive either the real light therapy or a sham device. The goal is to see if the treatment improves tear film …

This study tests whether Acoltremon 0.003% eye drops can quickly relieve symptoms like burning, irritation, and blurriness in people with moderate-to-severe dry eye disease. Fifty adults will use the drops as directed and report their symptom changes over 28 days. The goal is to …

This study tests a red-light mask (low-level light therapy) for treating dry eye and meibomian gland disease in 15 children with severe symptoms. It compares the light mask to standard care (warm compresses and artificial tears). The goal is to see if the light mask improves glan…

This study tests whether applying menthol solution to the cheek can release vapors that stimulate cold sensors on the eye, triggering natural tear production. Thirty healthy adults will receive either menthol or a placebo on one cheek, and researchers will measure if tears overfl…

This study tests a device called Rexon-Eye that uses gentle electrical pulses to treat dry eye disease. Thirty adults aged 18 to 40 will receive either real or sham treatment once a week for four weeks. Researchers will check if symptoms improve and analyze tear samples to unders…

This study tracks 378 people with moderate to severe dry eye disease and healthy volunteers to see how signs, symptoms, and biomarkers change after treatment with either Vevye or Xiidra eye drops. The goal is to find better ways to measure the disease and its response to therapy.…

This study looks at how keratoconus, a disease that thins and bulges the cornea, affects electrical signals in the eye and brain. Researchers will measure these signals in 50 adults with different stages of keratoconus using standard eye tests. The goal is to see if these measure…

This study aimed to compare how corneas with Fuchs endothelial corneal dystrophy (FECD) and healthy corneas swell and recover after wearing a contact lens for three hours. Researchers planned to measure corneal thickness before and after the lens was removed, tracking swelling an…

This study looks at whether corneas from donors with diabetes work as well as those from donors without diabetes after a specific type of corneal transplant called DMEK. Researchers will track 570 participants for 5 years to measure cell loss and overall transplant success. The g…

This study uses a special light-based technique called Brillouin microscopy to measure the stiffness of the cornea in people with keratoconus, a condition where the cornea thins and bulges. Researchers will compare measurements before and after treatments like corneal cross-linki…

This study looks at how common nerve problems are in people who feel eye discomfort. Researchers will test 1,000 participants to see if their pain is linked to nerve damage rather than just dry eye. The goal is to better understand these conditions and improve diagnosis.

This study looks at how well a new test called quantitative sensory testing (QST) can measure nerve function in the eye. Researchers will use heat, cold, and vibration to see how people with dry eye disease or corneal nerve damage respond. The goal is to better understand eye pai…

This study is testing whether a special microscope (in vivo confocal microscopy) can reliably detect tiny nerve growths called microneuromas in the cornea, which may be a sign of neuropathic corneal pain. Researchers will scan the eyes of 438 adults with dry eye or ocular pain to…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…