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Contact lens stress test for fuchs dystrophy eyes

NCT ID NCT04175938

Knowledge-focused Sponsor: Massachusetts Eye and Ear Infirmary Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to compare how corneas with Fuchs endothelial corneal dystrophy (FECD) and healthy corneas swell and recover after wearing a contact lens for three hours. Researchers planned to measure corneal thickness before and after the lens was removed, tracking swelling and recovery time. However, the study was withdrawn before enrolling any participants, so no results are available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Subjects in the Fuch's Dystrophy arm of the study must meet following criteria: * Have a clinical diagnosis of Fuchs endothelial corneal dystrophy * Be scheduled for corneal transplantation in the next 6 months * Have no history of prior ocular surgery in study eye * Have no history of contact lens intolerance * Be motivated and willing to complete ocular imaging tests Subjects in the healthy eyes arm of the study must meet following criteria: * Have no prior history of ocular disease including ocular surface disease or glaucoma * Have no history of prior ocular surgery in study eye * Have no history of contact lens intolerance * Be motivated and willing to complete ocular imaging tests Exclusion Criteria: Pregnant women \-

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Conditions

The condition(s) this trial relates to.

Fuchs' endothelial dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fuchs endothelial corneal dystrophy

Contacts and locations

Locations

  • Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.