Massachusetts Eye And Ear Infirmary

This study tests whether treating donor corneal tissue with a special cross-linking process before transplant can make it stronger and less likely to be rejected. The trial involves 96 adults who need a high-risk cornea transplant due to blood vessel growth in the eye. Researcher…

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) all done at the same time as cataract surgery. The goal is to see which one lowers eye pressure best and has the fewest side effects. About 243 adults with mild…

This study tests whether N-acetyl cysteine (NAC) eye drops can lower harmful oxidative stress in the eyes of people with Fuchs endothelial corneal dystrophy, a condition that clouds the cornea. About 45 adults who need cornea surgery will use the drops for 28 days before their op…

This early-stage study tests a special contact lens that slowly releases medicine to treat recurrent cystoid macular edema, a condition causing vision loss from fluid buildup in the eye. Six adults who need steroid treatment will wear the lens for up to 28 days. The goal is to se…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. Researchers will stu…

This study tests whether a topical eye drop called netarsudil can prevent the formation of harmful scar tissue (proliferative vitreoretinopathy) after retinal detachment repair. About 48 adults undergoing surgery for a detached retina will receive the drops before and after their…

This study tests special prism glasses designed to expand the side vision of people with tunnel vision or hemianopia (loss of half their visual field). About 20 participants will try different prism designs during several visits to see which works best for spotting obstacles whil…

This study tests a small, TENS-like device that gives mild electrical stimulation to see if it can improve balance and walking in older adults. About 120 people aged 60 and older will do tasks like walking for 6 minutes and standing on foam while wearing the device. The goal is t…

This study looks at how the brain functions differently in people with laryngeal dystonia (a voice muscle spasm condition) and voice tremor (a shaking voice). Researchers will use brain scans like MRI and EEG to compare patients and healthy volunteers. The goal is to better under…

This study looks at how cochlear implants affect hearing development in both children and adults. Researchers will test new ways to program these devices to improve speech understanding. The goal is to learn how listeners adapt over time and to create better programming methods f…

This study aims to better understand and classify different types of voice problems in people with laryngeal dystonia and voice tremor. Researchers will use voice tests and movement analysis to identify distinct symptom patterns. The goal is to improve diagnosis and guide future …

This study tests whether measuring how quickly your eyes adjust to the dark can serve as an early sign that high-dose atorvastatin is working for intermediate age-related macular degeneration (AMD). About 21 participants will take the statin and undergo regular dark adaptation te…

This study is testing a blood test (liquid biopsy) to see if it can find tiny bits of cancer DNA left behind after surgery for a type of skin cancer called cutaneous squamous cell carcinoma. It will also check if the test can track how well immunotherapy is working. About 60 peop…

This study looks at brain activity and structure in people with different types of focal dystonia (like writer's cramp or spasmodic dysphonia), their unaffected relatives, and healthy volunteers. The goal is to find distinct brain changes that cause these movement disorders. Abou…

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …