Could a simple eye drop stop blindness after retinal detachment?

NCT ID NCT06033703

Recruiting now Prevention Sponsor: Massachusetts Eye and Ear Infirmary Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether netarsudil eye drops can prevent proliferative vitreoretinopathy (PVR), a scarring condition that can cause retinal detachment surgery to fail. Researchers will check how much of the drug reaches the back of the eye and whether it is safe. The trial enrolls 48 adults undergoing retinal detachment repair.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Netarsudil eye drops (Rhopressa)
What this could lead to: If it works, this could point toward a simple eye drop treatment to prevent vision-threatening scar tissue after retinal detachment surgery.
What could go wrong: This is an early Phase 1/2 trial with only 48 participants, so it is too small to prove effectiveness. The drug must reach the back of the eye, which is not guaranteed, and safety is still being assessed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

proliferative vitreoretinopathy retinal detachment rhegmatogenous retinal detachment

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROLIFERATIVE VITREORETINOPATHY RHEGMATOGENOUS RETINAL DETACHMENT

Contacts and locations

Locations

Mass Eye and Ear
RECRUITING

Boston, Massachusetts, 02114, United States

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