Could a light treatment for donor eyes save more sight?

NCT ID NCT06753916

Recruiting now Disease control Sponsor: Massachusetts Eye and Ear Infirmary Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether treating donor corneal tissue with a special light-based process (cross-linking) before transplant can make it last longer and reduce rejection in people at high risk of graft failure. About 96 adults who need a high-risk cornea transplant will receive either a treated or standard donor cornea. The main goal is to check safety and see if the treated tissue lowers the chance of rejection or graft failure over two years.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEAL TRANSPLANT FAILURE

Contacts and locations

Locations

Cincinnati Eye Institute
RECRUITING

Cincinnati, Ohio, 45242, United States
Duke University - Duke Eye Center
RECRUITING

Durham, North Carolina, 27705, United States
Kansas City Eye Clinic
RECRUITING

Overland Park, Kansas, 66204, United States
Massachusetts Eye and Ear
RECRUITING

Boston, Massachusetts, 02114, United States
Mid-Atlantic Cornea Consultant
NOT_YET_RECRUITING

Towson, Maryland, 21204, United States
Price Vision Group
RECRUITING

Indianapolis, Indiana, 46260, United States
The University of California Los Angeles - Doris Stein Eye Research Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
University of California Irvine - Gavin Herbert Eye Institute
NOT_YET_RECRUITING

Irvine, California, 92617, United States
University of California San Francisco - Wayne and Gladys Valley Center for Vision
NOT_YET_RECRUITING

San Francisco, California, 94158, United States
University of Miami - Bascom Palmer Eye Institute
RECRUITING

Miami, Florida, 33136, United States
University of Michigan - Kellogg Eye Center
RECRUITING

Ann Arbor, Michigan, 48015, United States
Wake Forest Baptist Eye Center
NOT_YET_RECRUITING

Bermuda Run, North Carolina, 27006, United States

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