New eye drops aim to boost vision recovery after cornea surgery

NCT ID NCT05795699

First seen Apr 04, 2026 · Last updated May 08, 2026 · Updated 7 times

Summary

This phase 3 study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea surgery (descemetorhexis). 107 adults participated, receiving either the eye drops or a placebo for 12 weeks, followed by a gradual stop and 38 weeks of follow-up. The main goal was to see how quickly vision improved. The study is complete, and results will show if the drops are safe and effective.

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Contacts and locations

Locations

  • Aarhus Universitetshospital

    Aarhus N, Central Jutland, 8200, Denmark

  • Althaia Xarxa Assistencial Universitaria Manresa

    Manresa, Barcelona, 08243, Spain

  • Bascom Palmer Eye Institute

    Miami, Florida, 33418, United States

  • Bascom Palmer Eye Institute - Naples

    Naples, Florida, 34103, United States

  • Byers Eye Institute at Stanford

    Palo Alto, California, 94303, United States

  • Casey Eye Institute - OHSU

    Portland, Oregon, 97239, United States

  • Devers Eye Institute

    Portland, Oregon, 97210, United States

  • Dr. Greg Moloney

    Vancouver, British Columbia, V5Z 1K1, Canada

  • Eye Associates of New Mexico

    Albuquerque, New Mexico, 87109, United States

  • Eye Consultants of Atlanta

    Atlanta, Georgia, 30339-5971, United States

  • Gorovoy MD Eye Specialists

    Fort Myers, Florida, 33907, United States

  • Grene Vision Group

    Wichita, Kansas, 67208-3648, United States

  • Hospital Arruzafa

    Córdoba, Córdoba, 14012, Spain

  • Hospital Universitario Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Houston Eye Associates

    Houston, Texas, 77025, United States

  • Institut Catala de Retina (ICR)

    Barcelona, 08022, Spain

  • Instituto Oftalmologico Fernandez Vega

    Oviedo, Principality of Asturias, 33012, Spain

  • Instituto de Microcirugia Ocular

    Barcelona, 08035, Spain

  • Jules Stein Eye Institute

    Los Angeles, California, 90095, United States

  • Keck Hospital of USC

    Los Angeles, California, 90033, United States

  • LMU Klinikum der Universität

    München, 81377, Germany

  • Macy Eye Center

    Los Angeles, California, 90048, United States

  • Massachusetts Eye and Ear Infirmary

    Boston, Massachusetts, 02114, United States

  • Moorfields Eye Hospital

    London, London, City of, EC1V 2PD, United Kingdom

  • NYU Langone Health

    New York, New York, 10017, United States

  • Oftalvist - Barcelona

    Barcelona, 08017, Spain

  • Ottawa Hospital

    Ottawa, Ontario, K1H 8L6, Canada

  • Precision Cornea Centre

    Ottawa, Ontario, K1G 5L1, Canada

  • Prism Eye Institute - Mississauga-Oakville

    Oakville, Ontario, L6H 0J8, Canada

  • R and R Eye Research, LLC.

    San Antonio, Texas, 78229, United States

  • Rigshospitalet Glostrup-Nordre Ringvej 57

    Glostrup Municipality, Capital, 2600, Denmark

  • Royal Victoria Infirmary

    Newcastle upon Tyne, Northumberland, NE1 4LP, United Kingdom

  • Sacramento Eye Consultants

    Sacramento, California, 95815, United States

  • The Royal Liverpool University Hospital

    Liverpool, Lancashire, L7 8XP, United Kingdom

  • Uniklinik Köln

    Cologne, North Rhine-Westphalia, 50931, Germany

  • Universitatsklinikum Dusseldorf

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Universitatsklinikum Leipzig

    Leipzig, Saxony, 04103, Germany

  • Universitatsklinkum Erlangen-Ulmenweg 18

    Erlangen, Bavaria, 91054, Germany

  • University Hospitals Cleveland Medical Center - 11100 Euclid Ave

    Cleveland, Ohio, 44106, United States

  • University of Florida

    Gainesville, Florida, 32605, United States

  • University of Kentucky

    Lexington, Kentucky, 40508, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Wisconsin - 2870 University Ave

    Madison, Wisconsin, 53705, United States

  • Universität des Saarlandes

    Homburg, Saarland, 66424, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitätsklinikum Tübingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Vance Thompson Vision - Omaha

    Omaha, Nebraska, 68137, United States

  • Vance Thompson Vision West Fargo

    West Fargo, North Dakota, 58078, United States

  • Verdier Eye Center

    Grand Rapids, Michigan, 49546, United States

  • W Kellogg Eye Center

    Ann Arbor, Michigan, 48105, United States

Conditions

Explore the condition pages connected to this study.