Can eye drops offer a new way to treat fuchs dystrophy?

NCT ID NCT05376176

Completed Disease control Sponsor: Santen Inc. Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This clinical trial is testing whether an investigational eye drop called STN1010904 can improve vision in people with Fuchs endothelial corneal dystrophy (FECD), a condition that damages the cornea's inner layer and can lead to blurry vision. The study will compare two different strengths of the eye drop against a placebo (inactive solution) in about 86 adults with FECD. Participants will use the assigned eye drops twice daily for 18 months, and researchers will measure changes in visual acuity and contrast sensitivity to see if the treatment helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: STN1010904 ophthalmic suspension (eye drops)
What this could lead to: If successful, this could lead to a non-surgical treatment option for Fuchs endothelial corneal dystrophy, potentially delaying or avoiding the need for corneal transplant surgery.
What could go wrong: This is an early-phase (IIa) study with a small number of participants, so results may not be conclusive. The eye drops may not improve vision significantly or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fuchs' endothelial dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUCHS ENDOTHELIAL CORNEAL DYSTROPHY

Contacts and locations

Locations

Comprehensive Eye Care, Ltd

Washington, Missouri, 63090, United States
Devers Eye Institute

Portland, Oregon, 97210, United States
Fondation Ophtalmologique Adolphe de Rothschild

Paris, 75019, France
Houston Eye Associates

Houston, Texas, 77025-1697, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical Research Foundation

Chennai, Tamil Nadu, 600 006, India
Metropolitan Eye Research and Surgery Center

Palisades Park, New Jersey, 07650, United States
Price Vision Group

Indianapolis, Indiana, 46260, United States
Scott Christie and Associates

Cranberry Township, Pennsylvania, 16066, United States
Stein Eye Institution UCLA

Los Angeles, California, 90095, United States
Suven Clinical Research CenterL V Prasad Eye Institute

Banjara Hills, Telangana, 500034, India
Tauber Eye Center

Kansas City, Missouri, 64111, United States
UPMC

Pittsburgh, Pennsylvania, 15213, United States
University Hospital of Saint-Etienne

Saint-Etienne, 42055, France

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