Corneal disorder

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This study will test a special gel that can be injected into the eye to seal wounds on the cornea (the clear front part of the eye) without needing stitches. The gel turns from liquid to solid inside the eye and helps the cornea heal naturally. About 30 adults with certain types …

This study compares two approved cyclosporine eye drops—Vevye (0.1%) and a generic (0.05%)—in 60 adults with dry eye disease. Over 8 weeks, researchers will measure changes in goblet cells, which produce mucus to keep eyes moist. Participants use drops daily and visit the clinic …

This study tests a special hydrogel that acts like a glue to hold eye tissues together during surgery, avoiding the need for stitches. Stitches can cause pain, swelling, and scarring, but this gel uses light to bond quickly and gently. The trial will include 20 people with cornea…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This Phase 3 trial tests whether a disc made from donated human amnion membrane can help people with moderate to severe dry eye disease. The disc is placed on the eye and compared to standard care like lubricating drops and a bandage lens. The study will enroll 40 adults who have…

This study tests whether treating donor corneal tissue with a cross-linking procedure before transplant can improve vision and reduce astigmatism in people with keratoconus. About 216 adults aged 18–50 who need a corneal transplant will receive either cross-linked or standard don…

This study tests a combination of darolutamide, hormone therapy, and a lower dose of the chemotherapy drug docetaxel in men with metastatic hormone-sensitive prostate cancer. The goal is to see if this approach can keep PSA levels very low (below 0.2 ng/mL) at 24 weeks while redu…

This study tests whether injecting stem cells into the eye can help people with severe dry eye caused by graft-versus-host disease (GVHD), a complication of bone marrow transplants. The trial will include 30 adults who have not improved with standard treatments. Participants will…

This study tests a permanent artificial implant called EndoArt for people with long-term corneal swelling who have had multiple failed cornea transplants and cannot have another one. The implant acts as a barrier to stop fluid from entering the cornea. The study will check safety…

This study will test whether adding a salt water (sodium chloride 5%) eye drop to standard antibiotic treatment helps heal bacterial eye infections faster. About 40 adults with bacterial keratitis will receive either antibiotics plus the salt drop or antibiotics alone. The goal i…

This early study tests a 3D-printed human collagen implant in 4 people with severe corneal melting, a condition where the eye's clear front layer thins and can perforate. The implant is placed on the eye to reinforce the cornea and prevent vision loss. The main goal is to check i…

This early-phase trial tests whether adding a dietary supplement called LC-K76 to standard hormone therapy is safe for men with metastatic hormone-sensitive prostate cancer. Forty men will receive the supplement plus hormone therapy for 24 weeks, then be followed for another 24 w…

This pilot study tests a procedure called PRK-Plus, which combines laser vision correction with corneal cross-linking to treat thin, suspicious corneas. The goal is to improve vision and strengthen the cornea to prevent future problems. Sixty participants with thin corneas and ce…

This study compares two surgical techniques for preventing regrowth of a pterygium, a non-cancerous eye growth. After removing the growth, surgeons will cover the area with either a rotated flap of nearby tissue or a free graft from under the eyelid. 342 patients will be randomly…

This study tests a new gel called IVIEW-1201 for treating fungal keratitis, a serious eye infection. About 60 people will receive either the gel or a control treatment. The goal is to see if the gel can clear the infection and heal the eye. While it aims to cure the infection, on…

This study aims to create an artificial intelligence system that can automatically analyze confocal microscopy images of the cornea to diagnose dry eye disease. Researchers will collect eye scans from 75 adults (healthy and with dry eye) to train and test the AI. The goal is to r…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This study tests a compact, handheld eye imaging device that takes pictures of the eye in seconds. Researchers want to see if it is easy to use, mobile, and reliable. The device will be tested on 70 people with eye complaints, and the images will be compared to official diagnoses…

This study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…

This study tests a small device that attaches to a smartphone to help diagnose dry eye disease. It takes special pictures of the eye's surface using different lights. The goal is to see if people can use it at home to get accurate results, compared to a standard eye exam. About 5…

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This early study tests a special contact lens that has a tiny pinhole built in. The idea is that the pinhole helps focus light better, improving vision for people with presbyopia (age-related blurry near vision) or keratoconus (a cone-shaped cornea). Sixteen adults will try the l…

This study compares a new eye drop (perfluorohexyloctane) with a standard one (sodium hyaluronate) for people whose eyes get dry from using screens for more than 6 hours a day. Participants aged 18 to 70 with mild to moderate dry eye will use the drops four times daily for 8 week…

This study tests whether acoltremon eye drops can improve symptoms and tear production in people with dry eye disease over 12 months. Sixty adults will be randomly assigned to receive either the active drug or a standard artificial tear. Researchers will track changes in eye disc…

This study looks at whether a gel-like filler placed in the tear ducts can improve dry eye symptoms and make eye measurements more accurate before cataract surgery. About 65 adults with dry eye disease will be observed. The goal is to see if treating dry eye first leads to better…

This study compares two types of artificial tears for dry eye disease: one with preservatives and one without. Researchers want to see which is safer and more effective over 8 weeks. About 80 adults with dry eye will take part, and neither they nor their doctors will know which t…

This Phase 3 trial tests whether CAM-101 eye drops can reduce eye discomfort and corneal damage in people with moderate to severe dry eye. About 475 adults will receive either CAM-101 or a placebo for 9 weeks, then all participants can switch to CAM-101 for a year. The study aims…

This study compares a new eyelid support plate to a standard glass rod for eyelid massage in people with dry eye from meibomian gland dysfunction. 142 adults will receive either the new device or standard massage, plus eye drops, over 8 weeks. The goal is to see which method bett…

This phase 2 trial tests whether adding a steroid eye drop (fluorometholone) to standard antibiotic treatment improves vision at 3 months in people with bacterial corneal ulcers. About 174 adults with mild to severe ulcers will be randomly assigned to get either the steroid plus …

This study tests an experimental eye drop called RCI001 in 200 adults with dry eye disease. Participants will use the drops or a placebo for 4 weeks. The goal is to see if RCI001 reduces eye discomfort and damage to the eye's surface better than placebo. The study is not yet recr…

This study tests a device called TearCare that warms the eyelids and manually clears blocked oil glands in young adults (ages 18-29) with dry eye disease. 45 participants will receive one treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. T…

This small study tests whether a special VR headset, called Lacrima VR, can improve dry eye symptoms in people with dry eye disease and meibomian gland dysfunction. Twenty adults will either get the active treatment (light pulses through the headset) or a sham version with dimmer…

This study will observe 300 adults who have cataract surgery to see which of three tear substitute eye drops works best for reducing dry eye and discomfort. The drops contain different combinations of sodium hyaluronate, dexpanthenol, trehalose, and amino acids. Researchers will …

This study tests whether simply taping the eyelids shut during general anesthesia is enough to protect the cornea, or if adding lubricant eye drops is better. Two hundred adults having non-eye surgery will be randomly assigned to one of the two methods. The main goal is to see ho…

This study tests whether a structured blinking exercise can improve dry eye symptoms in adults with glaucoma who use eye drops. 45 participants will perform 15 close-squeeze-open blinks three times daily for two weeks. Researchers will measure symptom changes and tear film stabil…

This study tests lifitegrast eye drops (Xiidra) in 30 adults with dry eye disease. Researchers will use a special microscope to see if the drops reduce immune cells on the eye surface. The goal is to ease dry eye symptoms and understand how the treatment works.

This study will follow 100 people with keratoconus or corneal ectasia who undergo CTAK surgery. Researchers will use a questionnaire before and after surgery to measure changes in vision quality and overall quality of life. The goal is to see if this surgical approach helps patie…

This study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…

This early-stage study tests whether a new eye ointment called RC017 is safe and tolerable in 24 healthy adults aged 18 to 55. The ointment is being developed to treat dry eye disease. Participants will receive either the ointment or a placebo, and researchers will monitor for si…

This study compares two behavioral interventions—Baduanjin (a gentle 10-15 minute exercise) or laughter exercises using a smartphone app—plus artificial tears, against artificial tears alone for treating dry eye disease. About 540 adults aged 18-45 with moderate dry eye will part…

This study will test perfluorohexyloctane eye drops, the only approved drug in China for dry eye disease related to meibomian gland dysfunction. Researchers plan to enroll 2000 adults and track their symptoms, eye health, and any side effects over 12 weeks. The goal is to see how…

This study will test a new type of artificial lens, called the PureSee IOL, in 10 people who need surgery for both cataracts and a cornea condition called Fuchs dystrophy. The goal is to see if this lens helps patients see well at different distances and reduces their need for gl…

This study tests a blink reminder program called 'BlinkEasy' in 28 adults aged 18–40 who use screens at least 4 hours a day and have dry eye symptoms. Over three months, researchers will measure if the app slows the loss of oil glands in the eyelids and improves eye comfort. Part…

This study compares two common eye drops—rebamipide and diquafosol—for managing dry eye in people having cataract surgery. Sixty adults with mild to moderate dry eye will use one of the drops four times a day, starting one month before surgery and continuing for three months afte…

This study tests whether VMX eye drops can improve tear film stability and reduce dry eye symptoms compared to standard care. About 76 adults with mild to moderate dry eye disease will receive either VMX drops or a control. The main goal is to see if the drops help eyes stay mois…

This study tests acoltremon eye drops in 60 adults with dry eye disease to see if they improve symptoms like discomfort and blurry vision. Participants will complete surveys over three months to track changes. The goal is to understand how well the drops work in everyday life for…

This study tests whether eyedrops made from Kelulut honey (from stingless bees) are safe and can ease dry eye symptoms. 45 adults will use one of three strengths of honey drops three times a day for a month, while continuing their usual treatments. Researchers will check tear sta…

This study tests whether switching from Restasis to a new eye drop called acoltremon 0.003% can better relieve dry eye symptoms and improve tear production. About 100 adults with chronic dry eye who are dissatisfied with Restasis will take part. Researchers will measure changes i…

This study looks at whether switching from the dry eye drop Xiidra to a new drop called TRYPTYR (acoltremon 0.003%) can improve symptoms and tear production. About 100 adults with chronic dry eye who are already using Xiidra will take part. Researchers will measure tear productio…

This study tests a new eye drop called BRM421 against standard artificial tears in 99 adults with dry eye disease. The goal is to see if BRM421 is safe and better at reducing eye damage and discomfort. Participants will use the drops for 6 weeks, and doctors will measure changes …

This study will use a special imaging device (AS-OCT) to measure the thickness of the cornea's outer layer in 360 adults with nearsightedness, farsightedness, astigmatism, or normal vision. The goal is to see if different vision problems have unique thickness patterns. Participan…

This study aims to understand why some patients with severe dry eye syndrome improve with autologous serum eye drops while others do not. Researchers will analyze the protein makeup of the drops from 68 participants over 6 months. The goal is to identify which proteins are linked…

This study will measure eye pressure in one person with mild keratoconus before and one month after corneal cross linking. The goal is to see how the treatment changes eye pressure using a special device called Corvis CT. This is an observational study, not a treatment trial.

This study will follow 421 people with keratoconus, a condition that thins and bulges the cornea, to learn how it progresses and what factors increase risk. Researchers will use eye exams and imaging to track changes over time. The goal is to improve how doctors manage the diseas…

This study looks at whether dry eye disease makes it harder to calculate the right lens power for cataract surgery. Researchers will compare 100 patients with and without dry eye to see if those with dry eye have less accurate lens measurements. The goal is to find out if treatin…

This study looks at how blinking behavior is linked to the stability of the tear film in adults aged 18 to 65, both with and without dry eye symptoms. Participants will answer a questionnaire, have their vision checked, and undergo non-invasive tear film measurements using an ima…

This study will measure changes in tear fluid proteins in 36 adults with dry eye disease who are already using lifitegrast (Xiidra) eye drops. Researchers want to see how the drug affects these biomarkers over 84 days. The goal is to better understand dry eye and how the treatmen…

This study will test a new type of eye imaging called OCT in 24 adults who have had a cornea transplant. The goal is to see if the new method can take clearer pictures of the eye to help doctors better detect eye diseases. Participants will have their eyes scanned with the new de…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will track 50 newly diagnosed patients to see how different gene patterns affect treatment resp…

This study compares how two types of sedation affect tear production in 52 adults undergoing angioplasty. One group gets dexmedetomidine, the other gets standard sedatives like midazolam and fentanyl. Tear production is measured before, right after, and 12 hours after the procedu…

This study aims to learn more about microbial keratitis, a serious eye infection, by examining 100 patients at Assiut University Hospital. Researchers will identify the germs causing the infection, look for risk factors, and track complications and outcomes. The goal is to improv…

This study aims to find biological markers (biomarkers) in blood, tears, and eye cells from 110 adults with seven rare eye diseases. Researchers will compare these markers between patients and healthy controls to see if they differ and if they relate to disease symptoms. The goal…

This study will analyze corneal tissue that is normally thrown away during a common myopia surgery called CLEAR (or SMILE). Researchers will test the tissue's strength and structure to learn more about how the cornea behaves. The goal is to improve future eye surgeries by underst…