Could a simple Pre-Transplant treatment give keratoconus patients sharper vision?
NCT ID NCT04584125
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether treating donor corneal tissue with a cross-linking procedure before transplant can improve vision and reduce astigmatism in people with keratoconus. About 216 adults aged 18–50 who need a corneal transplant will receive either cross-linked or standard donor tissue. The goal is to see if the treated tissue stays stronger and leads to better long-term eyesight.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for KERATOCONUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, 02114, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a simple eyeglass test sharpen vision in keratoconus?
- Can a donor corneal lenticule patch up a thinning cornea?
- A piece of your own cornea might patch a thinning one — a trial puts it to the test
- Can a simple eye treatment stop the need for a corneal transplant?
- Eye insert could ease allergy symptoms for contact lens wearers
- Promising new eye treatment could halt vision loss from keratoconus