Eye scan could spot hidden nerve pain in dry eye sufferers

NCT ID NCT05653921

Terminated Knowledge-focused Sponsor: Tufts Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a special microscope (in vivo confocal microscopy) can reliably detect tiny nerve growths called microneuromas in the cornea, which may be a sign of neuropathic corneal pain. Researchers will scan the eyes of 438 adults with dry eye or ocular pain to see if the presence of microneuromas matches their symptoms. The goal is to validate this imaging technique as a diagnostic tool, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could provide a reliable way to diagnose neuropathic corneal pain using a simple eye scan, leading to better treatment decisions.
What could go wrong: The study is currently suspended, and it only aims to validate a diagnostic tool, not test a treatment. The biomarker may not prove reliable in all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

corneal disorder dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEAL DISEASE DRY EYE SYNDROMES

Contacts and locations

Locations

Scheie Eye Institute, University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States

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