PAIN, ACUTE

This study is testing if a simple nerve-block injection in the neck, given before breast cancer surgery, can prevent depression and chronic pain from developing afterward. It will involve 140 women undergoing a mastectomy. The goal is to see if this preemptive approach reduces th…

This study is testing whether vitamin C can help reduce pain from recent injuries like sprains, strains, or fractures in adults visiting the emergency department. Participants will take either vitamin C or a placebo pill for three days starting in the ER, and track their pain lev…

This study aims to find the best dose of a drug called dexmedetomidine to make a numbing injection for arm surgery last longer. Researchers will compare three different doses in 69 adults having elbow, forearm, or hand surgery. The main goal is to see which dose keeps the arm num…

This study is testing if a TENS unit, which uses mild electrical pulses on the skin, can reduce pain during a common outpatient procedure for stress urinary incontinence. 100 women will be randomly assigned to receive either a real TENS device or a placebo device during their pro…

This study is testing whether bright blue light therapy can help reduce pain and inflammation in adults hospitalized with painful rib fractures. Researchers will compare blue light to white light and normal hospital lighting, while all participants also receive standard pain trea…

This is a small, early-stage study to see if a new pain relief method is practical for people with broken ribs. The method, called cryoneurolysis, uses extreme cold to temporarily freeze the nerves that send pain signals from the broken ribs. Researchers will enroll 24 patients t…

This study is testing whether the hormone oxytocin can reduce pain. Researchers are comparing how well it works when given as a nasal spray versus through an IV drip in 24 healthy adults. Participants will have a small, controlled heat applied to their skin and rate their pain af…

This study is testing whether acupressure, a non-drug therapy using finger pressure on specific body points, can help people recover from major chest surgery. Researchers want to see if it reduces severe post-surgery pain and helps patients breathe and cough better, which could l…

This study is testing which of two pain control methods works better for patients having their gallbladder removed through keyhole surgery. It compares a newer nerve-blocking injection (external oblique intercostal block) with the standard method of numbing the small incision sit…

This is an early safety study testing a new oral medication called SBS-147, which is being developed to treat acute pain. Researchers will give the drug to healthy adults to check for side effects and see how the body processes it. Some participants will receive the actual drug w…

This study aims to understand why some patients develop long-term pain after a common eye surgery for keratoconus. Researchers will use brain scans and special eye imaging to track how pain signals change and how nerves in the eye heal after the procedure. The goal is to learn ho…

This study aims to understand how pain in leg muscles changes the way people walk. Healthy volunteers will receive injections that briefly cause muscle pain, and researchers will measure their walking patterns and muscle activity. The goal is to gather basic knowledge about pain …