PAIN, ACUTE

This study tests whether a nerve block given before mastectomy can prevent depression and chronic pain afterward. Researchers will compare 140 women who receive the block to those who do not. The goal is to see if this simple procedure can improve recovery and quality of life.

This early-phase trial tests whether disposable nitrous oxide (laughing gas) canisters can reduce pain and anxiety during burn dressing changes. Thirty adult burn patients will try both the gas and a placebo in random order. The goal is to see if this offers a safer alternative t…

This study tests whether a small electrical device (TENS) can reduce pain for women undergoing an in-office procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to se…

This study tests whether a gentle electrical stimulation device (acu-TENS) can reduce pain during a procedure called manual vacuum aspiration, used to treat early pregnancy loss. About 108 women will be randomly assigned to receive real acu-TENS or a sham device. The goal is to s…

This study tests whether adding a lightweight SAM splint to usual pain relief helps adults with suspected wrist fractures feel less pain while waiting for X-rays in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a sp…

This study tests a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their parents prepare for surgery. The app provides culturally tailored information and coping skills to reduce anxiety and pain. Researchers will compare the app to standard care in 120…

This study tests whether taking high-dose vitamin C for two weeks can lower the amount of opioid pain pills people need after leaving the emergency room with acute muscle or bone pain. About 464 adults will be randomly assigned to receive either vitamin C or a placebo. The goal i…

This study tests whether shining bright blue light on adults with painful rib fractures can reduce pain and inflammation. 75 hospitalized patients will be randomly assigned to receive blue light, white light, or standard hospital lighting for 4 hours each morning for up to 3 days…

This early-stage study tests the safety of an experimental pain drug called SBS-147 in 80 healthy adults. Some participants get the drug, others a placebo. The study has two parts: a single dose group and a group that takes the drug daily for a week. Researchers will monitor side…

This study tests whether vitamin C can reduce pain from recent muscle, bone, or joint injuries in emergency patients. Adults with moderate to severe pain are randomly given vitamin C or a placebo for three days. The goal is to see if this cheap, safe supplement can offer relief a…

This study tests whether acupressure can reduce pain and improve lung function in people recovering from thoracotomy (chest surgery). Eighty participants will receive acupressure or standard care. The goal is to see if this non-drug method can cut opioid use and side effects whil…

This study compares three doses of a medicine called dexmedetomidine, added to the numbing drugs used for nerve blocks during arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free for longer. About 69 adults having surgery below the elbow will take par…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study looks at why some people need extra opioids for pain after having their wisdom teeth removed, while others get enough relief from ibuprofen alone. Researchers will study 200 adults having at least one impacted wisdom tooth pulled. They hope to find clues in genes or bl…

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study looks at how muscle pain affects walking in healthy people aged 18 to 45. Participants receive six injections in leg muscles—some cause temporary pain, others do not—while their movements are tracked with cameras and force plates. The goal is to understand pain's effec…