PAIN, ACUTE

This study tests whether a stellate ganglion block (an injection near nerves in the neck) given before mastectomy can prevent depression and chronic pain after surgery. 140 women with breast cancer will be enrolled. The goal is to reduce the need for antidepressants and improve r…

This study tests three different doses of a drug called dexmedetomidine, added to the usual numbing medicine for a nerve block in the armpit area. The goal is to see if a higher dose can keep the arm numb and pain-free longer after elbow or hand surgery. About 69 adults having up…

This study tests whether oxytocin, given as a nasal spray or through an IV, can lower pain caused by heat on the skin. About 24 healthy adults will rate their pain after receiving the drug. Researchers also want to see if age, weight, or sex affect how well it works.

This study tests whether a handheld canister of nitrous oxide (laughing gas) can help control pain and anxiety during burn dressing changes. Thirty adults with burns covering 5-20% of their body will try both the gas and standard care to see which works better. The goal is to fin…

This study tests whether a small electrical device (TENS) can reduce pain during an outpatient procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. Researchers will measure pain …

This study tests a new way to manage pain from broken ribs by freezing the nerves that cause pain. It involves 24 adults with rib fractures who will receive either standard pain care plus the freezing treatment or standard care alone. The goal is to see if this approach is practi…

This study tests whether taking high-dose vitamin C for two weeks can lower the amount of opioid pain pills people need after leaving the emergency room for sudden muscle or bone pain. About 464 adults will be randomly assigned to receive either vitamin C or a placebo, and they w…

This study tests whether acupressure can reduce pain and improve lung function in 80 adults recovering from chest surgery. Participants will receive acupressure during rest and breathing exercises. The goal is to find a drug-free way to manage pain and reduce the need for opioids…

This study tests whether vitamin C can reduce pain from recent muscle, sprain, or fracture injuries in emergency patients. About 204 adults with moderate to severe pain will receive either vitamin C or a placebo for three days. The goal is to see if this cheap, safe vitamin can o…

This study tests whether a device called acu-TENS, which sends mild electrical pulses to acupuncture points without needles, can reduce pain during a procedure to treat early pregnancy loss. About 108 women will be randomly assigned to receive either real acu-TENS or a sham devic…

This study tests whether bright blue light therapy can reduce pain and inflammation in adults with painful rib fractures. About 75 hospitalized adults will be randomly assigned to receive blue light, white light, or usual room light for 4 hours each morning for up to 3 days, in a…

This study is testing a mobile app called L-WebTIPS, which was culturally adapted for Latinx families, to see if it can reduce anxiety and pain in children ages 2-7 having outpatient surgery. The app provides information, modeling, and coping skills to prepare children and their …

This study tests whether adding a simple aluminum splint to standard pain relief can reduce pain for adults with a suspected wrist fracture in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a splint or not. The main …

This study looks at why some people need extra pain medicine after getting their wisdom teeth out, while others get enough relief from ibuprofen alone. Researchers will study 200 adults having at least one impacted wisdom tooth removed. The goal is to find clues that could help d…

This study looks at how muscle pain changes the way healthy people walk. 36 adults aged 18-45 will get injections that cause temporary pain in leg muscles while their walking is measured with cameras and force plates. The goal is to better understand how pain alters movement, not…

This study looks at how pain signals in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye microscopes to track healing in 60 people aged 8-35. The goal is to understand pain bet…

This early-stage study tests a new oral drug called SBS-147 in 80 healthy adults to see if it is safe and how the body handles it. Some participants get the drug, others get a placebo. The study has two parts: a single-dose group and a 7-day multiple-dose group. It does not aim t…