PAIN, ACUTE

This study looked at whether taking ibuprofen for eight days after hip or knee replacement is safe. About 2904 adults took part. Researchers tracked serious problems like heart attack, stroke, bleeding, or kidney failure for 90 days after surgery.

This study tested if an ultrasound-guided nerve block (Serratus Anterior Plane Block) helps patients with rib fractures feel less pain and breathe easier. 40 adults with rib fractures received either the nerve block or usual care. Researchers measured pain, breathing, and cough a…

This study tested whether using virtual reality (VR) can lower the pain people feel from brief, hot but tolerable heat pulses. Twenty-four healthy adults rated their pain with and without VR, and sometimes received two heat pulses at once. The goal was to see if VR could distract…

This study looked at whether stimulating a baby's natural palmar grasp reflex (the instinct to grip a finger) can reduce pain and improve comfort in preterm infants during PICC line care. 32 preterm babies with a PICC line were included. Researchers measured pain and comfort leve…

This study looked at whether cognitive behavioral therapy (CBT) can help people who had surgery for a broken bone feel less pain over the next year. Over 1,000 adults took part, some getting CBT and others usual care. The goal was to see if CBT lowers the chance of developing lon…

This study tested whether a medicine called dexmedetomidine can help control pain in people with three or more broken ribs. The goal was to lower pain scores and reduce the need for strong opioid painkillers. The trial included 41 adults in the ICU after a blunt chest injury.

This study tested a 6-week nurse-led program delivered through a smartphone app to help breastfeeding women manage breast and nipple pain. About 250 new mothers who intended to breastfeed participated. The program provided education, skills, and text-based support from a nurse to…

This study looked at whether giving patients an open-label placebo (a pill they know has no active drug) can help manage sudden, non-specific pain in the emergency department. 57 adults with acute pain took part. The main goal was to see if this approach is practical and acceptab…

This study tested whether a virtual reality program that uses biofeedback (like calming games controlled by breathing) could help children and teens aged 12-18 manage pain after surgery. Researchers worked with 93 participants to see if the approach was practical and well-liked. …

This study tested whether hand reflexology or a simple hand massage could help reduce pain, anxiety, and improve vital signs in 70 adults who had a coronary angiography (a heart procedure). Participants received one of the two massage techniques, and their pain and anxiety levels…

This study compared two types of nerve blocks (ESP and QL block) to see which one works better for pain after abdominal surgery. 100 adults having surgery for cancer or gallbladder issues took part. The goal was to find which block reduces the need for strong painkillers and lowe…

This study tested whether a new online program can help people manage pain and reduce opioid use after surgery. The program teaches mindfulness and coping skills through videos and exercises, without a therapist. Researchers compared it to a workshop led by a psychologist to see …

This study tested two pain relief methods after hip replacement surgery: a continuous nerve block near the spine (erector spinae plane block) versus standard epidural pain relief. Researchers measured pain levels, opioid use, muscle strength, walking ability, and quality of recov…

This study looked at whether vitamin C can reduce pain sensitivity in healthy people. 38 volunteers took either vitamin C or a placebo, and researchers measured how much pressure they could tolerate before feeling pain. The goal was to see if vitamin C could be a safe, non-drug o…

This study looked at 46 adults having spinal surgery to find out if giving a nerve block (ESP block) before or after surgery works better for pain control. Researchers measured how much opioid pain medicine patients needed and their pain scores. The goal is to improve comfort and…

This study tested whether giving a low dose of ketamine over 30 minutes instead of 15 minutes reduces side effects like dizziness and confusion while still controlling severe pain. 55 adults with acute pain in the emergency department took part. The goal was to find a way to keep…

This study tested two methods to control pain after gallbladder removal surgery: a nerve block near the ribs versus numbing the surgical cuts. Sixty adults took part to see which approach reduced pain and the need for strong painkillers like morphine in the first 24 hours. The go…

This study tested whether breathing hydrogen gas before and after surgery could reduce pain and inflammation in 37 people having back surgery for a herniated disc. Researchers measured pain levels and blood markers of inflammation. The goal was to see if hydrogen inhalation is a …

This study tested whether breathing in morphine works as well as getting it through an IV for treating severe pain in the emergency department. 226 adults with intense pain were randomly assigned to receive either inhaled morphine plus a placebo IV, or IV morphine plus a placebo …

This study looked at how body mass index (BMI) influences pain levels after lumbar disc surgery when a nerve block is used for pain control. Researchers measured pain in 75 adults at different times after surgery. The goal was to see if higher BMI leads to more pain, which could …

This study looked at how a mild electrical stimulation on the ear (called taVNS) changes the way healthy people sense signals from inside their body, like pain, heartbeat, and temperature. Fifty healthy adults took part in two experiments to measure these effects. The goal was to…

This study looked at how short-term pain impacts the ability to learn and remember new walking patterns in 61 healthy young (18-35) and older (55-85) adults. Researchers measured how well participants learned and retained a new way of walking while experiencing pain, and compared…

This study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 adults with cirrhosis about their pain during a single 15-45 minute visit. The goal was to find out how common pain is in this group, since it is often overlooked. This is an…

This study looked at why some people feel a sharp increase in pain after a local anesthetic (numbing shot) wears off, a phenomenon called rebound pain. Forty healthy volunteers received a nerve block in one arm and had their pain sensitivity measured as the block faded. The goal …