Breathing in pain relief: inhaled morphine may offer faster ER treatment

NCT ID NCT03257319

Completed Symptom relief Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether breathing in morphine works as well as getting it through an IV for quickly treating severe pain in the emergency department. 226 adults with intense pain were randomly assigned to receive either inhaled morphine plus a placebo IV, or IV morphine plus a placebo inhaler. The main goal was to see how many patients had significant pain relief within one hour.

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Conditions

The condition(s) this trial relates to.

Acute Pain Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMERGENCIES MORPHINE PAIN, ACUTE

Contacts and locations

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Locations

AP-HP

Bobigny, France
CH Agen-Nérac

Agen, France
CH Eure Seine Hôpital d'Evreux

Évreux, France
CH Le Mans

Le Mans, France
CHI Robert Ballanger

Aulnay-sous-Bois, France
CHRU de Lille

Lille, France
CHU Gabriel Montpied

Clermont-Ferrand, France
CHU Grenoble

Grenoble, France
CHU Hôpitaux BORDEAUX

Bordeaux, France
CHU Nice

Nice, France
CHU de Caen

Caen, France
CHU-Hôpitaux de Rouen

Rouen, 76031, France
Chu Strasbourg

Strasbourg, France
GH Le Havre

Le Havre, France
Hopital COCHIN

Paris, France
Hospices civils de Lyon

Lyon, France
Hôpital Bichat-Claude Bernard

Saint-Ouen, France
Hôpital Lariboisière

Paris, France
La Pitié Salpétrière

Paris, France
chu de Toulouse

Toulouse, France

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