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Breathing in pain relief: inhaled morphine may offer faster ER treatment

NCT ID NCT03257319

Symptom relief Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether breathing in morphine works as well as getting it through an IV for quickly treating severe pain in the emergency department. 226 adults with intense pain were randomly assigned to receive either inhaled morphine plus a placebo IV, or IV morphine plus a placebo inhaler. The main goal was to see how many patients had significant pain relief within one hour.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

226 people

The number who actually took part.

Started

Sep 2017

Finished

Jul 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 and \<75 years old; * EVA ≥ 70/100 or EN ≥ 7/10; * Patient who received clear information from the investigator and read and signed the consent form; * Patient affiliated with, or beneficiary of a social security category; * For women: O of childbearing age: effective contraception (oral contraception, intrauterine device or use of condoms) O menopausal status (amenorrhoea less than 12 months before the inclusion visit) O objectivized sterility (diagnosis or surgically) Exclusion Criteria: * Chronic pain (\> 3 months) * Taking opioids longer than 10 days (including "weak" opioids tramadol and / or codeine); * Taking Rifampicin; * Impaired ability to discern, cognitive impairment; * Morphine-related contraindications: O Obstructive chronic obstructive or restrictive respiratory failure known or suspected compensated or not, O Hypersensitivity to the active substance or to any of the excipients, O Severe hepatocellular insufficiency (known or suspected), O Chronic renal failure known or suspected, O Uncontrolled epilepsy, O Cranial trauma (intracranial hypertension), O Associations with buprenorphine, nalbuphine, pentazocine and naltrexone * Active drug history or practice (s); * Evidence of reduced fracture or dislocation in emergency rooms; * Suspected occlusive syndrome * SaO2 \<95%; * FR \<12 / min; * Glasgow \<15 or other alertness disorders; * HR heart rate \<50 bpm and / or Auriculo-Ventricular block (PR XML File Identifier: zR6XOYKSEQ9GjQHghP8c465EwF0= Page 15/30 interval\> 200 ms); * Arterial hypotension with systolic blood pressure TA syst \<100 mm Hg; * Pregnant or nursing * Persons deprived of their liberty by an administrative or judicial decision, a person placed under the safeguard of justice, guardianship; * Patients with poor comprehension of spoken or written French; * Patients participating in another interventional clinical study; * Contra-indication related to the use of saline solution * Contra-indications related to the use of aerosol: O Necessity to access the face O Allergy known to plastic

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Conditions

The condition(s) this trial relates to.

Acute Pain Emergencies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Emergencies Morphine Pain, acute

Contacts and locations

Locations

  • AP-HP

    Bobigny, France

  • CH Agen-Nérac

    Agen, France

  • CH Eure Seine Hôpital d'Evreux

    Évreux, France

  • CH Le Mans

    Le Mans, France

  • CHI Robert Ballanger

    Aulnay-sous-Bois, France

  • CHRU de Lille

    Lille, France

  • CHU Gabriel Montpied

    Clermont-Ferrand, France

  • CHU Grenoble

    Grenoble, France

  • CHU Hôpitaux BORDEAUX

    Bordeaux, France

  • CHU Nice

    Nice, France

  • CHU de Caen

    Caen, France

  • CHU-Hôpitaux de Rouen

    Rouen, 76031, France

  • Chu Strasbourg

    Strasbourg, France

  • GH Le Havre

    Le Havre, France

  • Hopital COCHIN

    Paris, France

  • Hospices civils de Lyon

    Lyon, France

  • Hôpital Bichat-Claude Bernard

    Saint-Ouen, France

  • Hôpital Lariboisière

    Paris, France

  • La Pitié Salpétrière

    Paris, France

  • chu de Toulouse

    Toulouse, France

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