Common painkiller ibuprofen put to the test after joint surgery

NCT ID NCT05575700

Completed Disease control Sponsor: Naestved Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleeding for 90 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ibuprofen
What this could lead to: If ibuprofen is found safe, it could confirm a common painkiller as a standard option after joint replacement surgery.
What could go wrong: This is a completed Phase 4 trial, but results are not yet published. Ibuprofen can still cause stomach ulcers, kidney problems, or bleeding in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain agnosia arthropathy osteoarthritis, hip osteoarthritis, knee pain agnosia Pain, Postoperative Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA ANALGESIC ADVERSE REACTION HIP ARTHROPATHY KNEE ARTHROPATHY PAIN, ACUTE POSTOPERATIVE COMPLICATIONS POSTOPERATIVE PAIN SAFETY ISSUES

Contacts and locations

Locations

Aalborg University Hospital

Farsø, 9640, Denmark
Bispebjerg Hospital

Copenhagen NV, 2400, Denmark
Gentofte Hospital

Hellerup, 2900, Denmark
Nordsjællands Hospital Hillerød

Hillerød, 3400, Denmark
Næstved Hospital

Næstved, 4700, Denmark
Odense University Hospital

Odense, 3900, Denmark
Private Hospital Gildhøj

Brøndby, 2605, Denmark
Silkeborg Regional Hospital

Silkeborg, 8600, Denmark
Svendborg Hospital

Svendborg, 5700, Denmark
Vejle Sygehus

Vejle, 7100, Denmark
Zealand University Hospital

Køge, 4600, Denmark

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