PAIN, POSTOPERATIVE

This study is observing whether using a robot to assist surgeons during bladder removal surgery leads to less blood loss, less pain after surgery, and fewer blood transfusions for patients. Researchers will follow 60 patients undergoing this procedure at a major medical center. T…

This large international study is testing if giving an intravenous drug called lidocaine during breast cancer surgery can prevent patients from developing long-lasting pain months later. Over 1,600 patients will be randomly assigned to receive either the lidocaine infusion or a p…

This small pilot study is testing whether patients can safely and effectively self-administer liquid acetaminophen (Tylenol) for pain after shoulder replacement surgery. Researchers want to see if this approach is practical and acceptable to patients compared to nurses giving pil…

This study is testing whether a new local numbing technique works as well as standard spinal anesthesia for pain control after hip replacement surgery. Researchers want to see if the new method, which involves numbing medicine injected around the hip joint, provides similar pain …

This study is testing whether giving magnesium through an IV during hip surgery helps reduce pain afterward. Researchers want to see if this approach lowers pain scores and reduces the need for opioid pain medications. The study involves 64 people who are having a specific hip su…

This study aims to find which of two targeted nerve-block injections works better for pain relief after hernia repair surgery. Researchers will compare how long pain relief lasts and how much extra pain medication 60 patients need in the first day after surgery. The goal is to im…

This study compares two common anesthesia methods for patients having surgery to remove liver tumors. Researchers want to see if spinal anesthesia provides the same pain relief as epidurals while helping patients recover faster with fewer complications. They believe spinal anesth…

This study compares two different nerve block techniques to see which provides better pain relief after breast reduction surgery. Researchers will enroll 90 women having this surgery and randomly assign them to receive one of two ultrasound-guided nerve blocks before their operat…

This study is testing two different numbing injections to see which one better controls pain after hypospadias surgery in young boys. Seventy boys aged 1-5 will receive one of the two injections after they are asleep for surgery. Researchers will measure their pain levels and nee…

This study is testing if a small, non-invasive device placed on the ear can help reduce pain after back surgery. The device gently stimulates nerves to potentially lower pain signals to the brain. Researchers will compare it to a fake device in 20 patients to see if it helps peop…

This study is testing if adding a drug called dexmedetomidine to a standard pain-blocking injection works better for pain relief after abdominal surgery. Researchers will compare pain levels in 80 patients who get the new combination versus those who get the standard injection al…

This study compares two approaches to managing pain after knee surgery: traditional opioid medications versus non-opioid alternatives. Researchers want to see if common non-opioid medications work as well as opioids for pain relief while potentially avoiding opioid risks. The stu…

This study is testing whether a specific nerve block can better control pain after hip replacement surgery. Researchers will compare the standard painkiller ropivacaine against a placebo (saltwater) injection in 80 patients. The main goal is to see if this nerve block reduces pai…

This study is testing whether a device that uses pulsed electromagnetic fields (PEMF) can help reduce pain after knee or shoulder surgery. Researchers will compare the device to a placebo in 76 patients to see if it lowers pain scores and the need for pain medication 10 days afte…

This study is testing if a dressing made from Aloe Vera gel works better than a standard paraffin-based dressing to reduce pain where skin is taken for a graft. Researchers will compare pain levels and painkiller use in 72 adult patients one week after surgery. The goal is to fin…

This study is testing a new locked device designed to help patients use opioid pain medications more safely after spine surgery. Thirty patients having a common back operation will be split into two groups: one gets the new smart dispenser that unlocks only at scheduled times via…

This study is testing if giving methadone as a pill before surgery works as well as giving it through an IV during surgery to control pain afterward. It involves 100 adults having planned heart surgery. The main goal is to see which method better reduces the need for strong paink…

This study is testing if adding a long-acting numbing medicine called Exparel to standard care provides better pain relief and reduces the need for opioid painkillers after knee ligament reconstruction surgery. Researchers will compare teens and young adults who receive Exparel d…

This study aims to see if a specific type of injection in the back muscles (called an ESPB block) works better than standard skin-level injections at reducing pain and the need for opioid painkillers after lumbar spinal fusion surgery. Researchers will track pain levels and medic…

This study is testing if giving children the medication gabapentin around the time of chest surgery can safely reduce their need for strong opioid painkillers afterward. Researchers will compare 60 children who receive gabapentin to those who receive a placebo, measuring pain lev…

This study is testing if a device called VibraCool can help manage pain and reduce the need for opioid painkillers after ACL reconstruction surgery. Researchers will enroll 130 adults who have had this common knee surgery. They will compare pain levels and opioid use in people us…

This study aims to find the best and safest way to manage pain after common surgeries like gallbladder removal, hernia repair, and breast lump removal. It will compare two standard medication plans: one using common pain relievers like ibuprofen and acetaminophen, and another usi…

This study tests whether a small dose of morphine injected into the spinal fluid before chest surgery reduces pain and medication needs afterward. 90 adults having elective chest surgery will receive either the morphine injection or a placebo saline injection. Researchers will me…

This study is testing whether freezing specific nerves during rib fracture surgery helps patients experience less pain and need fewer opioid painkillers afterward. Researchers will compare patients who receive this nerve-freezing procedure (called cryoablation) during surgery to …

This study is testing whether patients having obesity surgery can get effective pain relief without opioids. Researchers are comparing standard opioid-based pain treatment against opioid-free approaches that use different medications and techniques. The goal is to see if avoiding…

This study is testing if applying a steroid directly to the spine during a common back surgery helps patients recover better. Researchers will compare patients who get the steroid to those who get a placebo to see if it reduces pain, shortens hospital stays, helps people return t…

This study is testing whether a specific nerve block, given before hip fracture surgery, helps control pain better after the operation. Researchers will compare 70 patients who receive the nerve block to those who get standard pain care. They will measure pain levels, need for ex…

This study compares two ways to deliver pain medication through nerve block catheters after surgery. Researchers want to see whether a steady drip or scheduled larger doses provides better pain control with fewer side effects like breathing problems. They're enrolling 240 adults …

This study aims to find out if giving children a single dose of a long-acting opioid (methadone) during tonsil removal surgery provides better and longer-lasting pain relief after the operation compared to standard short-acting opioids. Researchers will enroll 440 children and te…

This study compares two different methods for managing pain after kidney transplant surgery. Researchers want to see which approach works better to reduce pain and limit the need for opioid painkillers. The trial involves 200 adult patients who are receiving kidney transplants. O…

This study is testing if giving a single dose of gabapentin two hours before wisdom teeth removal can help control pain while reducing the need for opioid painkillers during and after the procedure. About 98 adults having their wisdom teeth pulled will receive either gabapentin o…

This study is testing whether a specific nerve block injection can better control pain for people getting a pacemaker or similar heart device implanted. 60 patients will be randomly assigned to receive either the real nerve block or a placebo injection. Researchers will measure p…

This study aims to find the best dose of a long-acting numbing medicine (liposomal bupivacaine) given as a nerve block to control pain after knee replacement surgery. Researchers will compare how well different doses reduce pain and the need for opioid painkillers in 177 adults u…

This study is testing whether a targeted numbing injection during minimally invasive pituitary surgery helps control pain afterward. About 108 patients will be randomly assigned to receive either the numbing medication, a saltwater placebo injection, or no extra injection during …

This study is testing whether a 12-week virtual dance program can help breast cancer survivors who have persistent pain after surgery. Researchers want to see if dancing improves pain, fatigue, body image, and overall quality of life. About 30 participants will take part in the o…

This study is testing which of two pain control methods works better for patients having their gallbladder removed through keyhole surgery. It compares a newer nerve-blocking injection (external oblique intercostal block) with the standard method of numbing the small incision sit…

This study looks back at medical records to see if using anesthesia without opioids leads to less confusion and agitation in children after ear, nose, and throat surgeries. It will compare about 120 children who received standard opioid-based anesthesia to those who received opio…

This study aims to understand why some patients develop long-term pain after a common eye surgery for keratoconus. Researchers will use brain scans and special eye imaging to track how pain signals change and how nerves in the eye heal after the procedure. The goal is to learn ho…