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Can we ditch opioids after surgery? new trial aims to find out

NCT ID NCT04659317

Recruiting now Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a standard opioid painkiller (oxycodone) to a placebo in people recovering from orthopedic surgery like joint replacements. The goal is to see if a non-opioid pain management plan can control pain just as well. About 80 adults having various orthopedic procedures will rate their pain and satisfaction over several months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Oxycodone 5 mg oral tablet and placebo oral tablet
What this could lead to
If successful, this could show that opioid-free pain control is effective after orthopedic surgery, reducing reliance on opioids.
What could go wrong
This is a small, early-phase trial with only 80 participants, so results may not apply to everyone. The non-opioid regimen might not control pain as well as opioids for some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia arthritic joint disease Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN PAIN, POSTOPERATIVE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Emory Orthopedic and Spine Hospital

    RECRUITING

    Tucker, Georgia, 30084, United States

    Contact Email: •••••@•••••

  • Emory University Hospital

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Email: •••••@•••••

  • The Emory Clinic

    RECRUITING

    Atlanta, Georgia, 30024, United States

    Contact Email: •••••@•••••

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