Could a One-Time spinal shot ease pain after lung surgery?

NCT ID NCT05351229

Recruiting now Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single injection of morphine into the spinal fluid can reduce pain and the need for other painkillers after video-assisted or robotic lung surgery. About 90 adults undergoing elective lung surgery will be randomly assigned to receive either the morphine injection or a placebo (salt water). Neither the patient nor the doctor will know which they received. The goal is to find a better way to manage post-surgery pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: morphine sulfate
What this could lead to: If it works, this could offer a simple, single-dose method to better control pain after lung surgery and reduce the need for other painkillers.
What could go wrong: This is a small, early-phase trial (90 people) testing a well-known drug for a new use. The effect may be small or not better than placebo, and morphine carries risks like nausea, itching, or breathing problems.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN, POSTOPERATIVE

Contacts and locations

Locations

University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

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