PAIN, POSTOPERATIVE

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent chronic pain that often follows. 260 women having breast-conserving surgery or mastectomy received either the anesthetic or a placebo. The main goal was to see if fewer…

This study tested whether adding acupuncture to standard anti-nausea medication can better prevent nausea and vomiting after gallbladder removal surgery. 270 adults scheduled for laparoscopic cholecystectomy received either acupuncture at specific points plus standard drugs, or s…

This study tested whether a dressing soaked with heparin, a common blood thinner, can prevent thick, raised scars and reduce pain at the site where skin is taken for a graft. 400 patients received both a standard dressing and a heparin dressing on different donor sites. The goal …

This study tested whether using a combination of pain medicines (magnesium, ketamine, lidocaine, and dexmedetomidine) along with some opioids helps patients recover better after major surgery compared to using opioids alone. 240 adults having planned major surgery took part. The …

This study tested two simple techniques—breathing yoga and progressive muscle relaxation—in 125 liver transplant recipients to see which better reduces pain, breathing complications, and fear of movement. Both methods are drug-free and can be done at home. The goal is to help pat…

This study tested whether injecting a long-lasting pain medicine (liposomal bupivacaine) into the breastbone area before the surgeon makes the cut can reduce the need for opioid painkillers after heart surgery. 70 adults having heart surgery through the breastbone took part. The …

This study looked at whether cognitive behavioral therapy (CBT) can help people who had surgery for a broken bone feel less pain over the next year. Over 1,000 adults took part, some getting CBT and others usual care. The goal was to see if CBT lowers the chance of developing lon…

This study tested whether placing small seeds on specific points of the ear (auricular acupressure) can help reduce pain after a cesarean section. Seventy women who had a C-section were randomly assigned to receive either real acupressure seeds or fake (sham) patches. Researchers…

This study tested whether taking melatonin for three nights before wisdom tooth removal can lower pain and the need for painkillers after surgery. Sixty adults aged 18-35 took either melatonin or a placebo before their procedure. Researchers measured how many pain pills participa…

This study tested whether giving a single dose of pregabalin (a nerve pain medication) about an hour before kidney stone surgery could reduce pain and the need for opioid painkillers afterward. 118 adults having ureteroscopy with a ureteral stent were randomly assigned to receive…

This study looked at whether duloxetine, a medication often used for depression or nerve pain, can help reduce pain and the need for strong painkillers after knee replacement surgery. 241 adults having knee replacement took part, and some received duloxetine while others got a pl…

This study looked at different ways to clean a tooth during a root canal to see which one causes the least pain afterward. 80 healthy adults with a dead tooth in the lower jaw took part. They received one of several cleaning methods, and their pain was checked at 6 hours, 24 hour…

This study tested different ways to manage pain after keyhole gallbladder removal in 160 adults. Some patients received a nerve block (TAP block), local anesthetic, both, or no extra pain relief. The TAP block group reported less pain and fewer wound problems in the first 24 hour…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain and getting patients moving sooner. One group got a fascia iliaca block, the other got a combination of adductor canal and IPACK blocks. The main goal was to me…

This study tested whether leaving surgical wounds uncovered after gastrointestinal cancer surgery is as safe as changing dressings every two days. Over 1,100 patients were randomly assigned to either no dressing changes or routine care. The goal was to see if skipping dressings c…

This study tested whether adding a long-lasting painkiller (Exparel) to standard numbing medicine helps control pain and reduce opioid use after foot and ankle surgery. About 248 adults having elective surgery took part. The main goal was to see how long the pain relief lasted an…

This study compared two common numbing medicines, lidocaine and bupivacaine, in 60 patients aged 15-35 having jaw surgery. Patients rated their pain and numbness on each side of the jaw to see which medicine worked better. The goal is to help surgeons choose the best anesthetic f…

This study tested two pain relief methods after rhinoplasty (nose surgery) in 159 adults. One group took acetaminophen with hydrocodone (an opioid), and the other took acetaminophen with ibuprofen (a common painkiller). Participants rated their pain on a 0-100 scale before and af…

This study tested whether a fixed-dose combination of dipyrone and codeine provides better pain relief than either drug alone after open pelvic-abdominal surgery. About 491 adults with moderate to severe pain after surgery took part. The main goal was to see how many people got a…

This study tested whether vibration therapy, alone or with cold, could reduce pain and anxiety when chest tubes are removed after heart bypass surgery. 93 adults were randomly assigned to vibration, vibration plus cold, or standard care. Results showed both vibration methods sign…

This study tested whether using the Headspace meditation app before surgery could help reduce pain after a minimally invasive hysterectomy. 72 women participated and reported their pain levels the day after surgery. The goal was to see if mindfulness training could improve recove…

This study tested two pain relief methods after total hip replacement: a nerve block (erector spinae plane block) versus morphine injected into the spine. 70 adults were randomly assigned to one of the two groups. The main goal was to see which method helped patients walk 10 step…

This study tested two different methods of pain control during back surgery to see which one works better. 29 adults having thoraco-lumbar fusion surgery received either a nerve block before surgery, numbing medicine injected at the end of surgery, or standard anesthesia alone. R…

This study looked at 60 adults having knee replacement surgery to compare two types of nerve blocks for pain relief. One group received a BiFeS block plus an adductor canal block, while the other got an IPACK block plus an adductor canal block. Researchers measured pain scores an…

This study tested whether a long-acting numbing medicine (liposomal bupivacaine) can reduce pain and the need for strong opioid painkillers after skin graft surgery. 74 burn patients with small burns took part. Researchers compared pain scores and opioid use between those who got…

This study tested whether wearing green or blue glasses after kidney donation surgery can help reduce pain and nausea without medication. 48 kidney donors were randomly assigned to wear green, blue, or clear glasses, or no glasses at all. Their pain and nausea levels were checked…

This study tested whether a virtual reality program that uses biofeedback (like calming games controlled by breathing) could help children and teens aged 12-18 manage pain after surgery. Researchers worked with 93 participants to see if the approach was practical and well-liked. …

This study looked at 670 women who had a hysterectomy to see if giving morphine through a spinal injection works better than through an IV for controlling pain. The goal was to find a way to reduce pain and the need for strong painkillers after surgery. Researchers measured pain …

This study tested an eye drop called OCS 01 in 153 adults who had cataract surgery. The goal was to see if it could reduce eye inflammation and pain better than a placebo drop. Participants used the drop once or twice a day for a short time after surgery.

This study looked at whether watching comedy shows (comedy therapy) could help patients feel less pain and anxiety after a type of kidney stone surgery called Uretero-Renoscopy. 110 adults who had the surgery took part. The goal was to see if laughter could be a simple, drug-free…

This study tested two types of nerve blocks to reduce pain in children after hip surgery. 80 children aged 1-7 years received either a caudal block or a pericapsular nerve group (PENG) block. The goal was to see which block provides better pain control and reduces the need for st…

This study looked at whether a TAP block (a type of nerve block) can lower pain after laparoscopic gallbladder removal. Sixty adults having this surgery were split into two groups: one got the TAP block with numbing medicine, the other did not. Researchers measured pain levels an…

This study tested two different pain relief medicines given through a small tube near the spine after video-assisted lung surgery. 90 adults took part to see if adding sufentanil to ropivacaine reduces pain better than ropivacaine alone. The main goal was to measure how much morp…

This study tested two pain relief methods after hip replacement surgery: a continuous nerve block near the spine (erector spinae plane block) versus standard epidural pain relief. Researchers measured pain levels, opioid use, muscle strength, walking ability, and quality of recov…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block could lower the need for …

This study tested if a special nerve block (SPSIPB) can reduce pain in adults getting a heart device like a pacemaker. Sixty people took part, receiving either the nerve block with numbing medicine or a sham injection. Researchers measured pain levels during and up to 24 hours af…

This study tested two pain relief methods after liver surgery: continuous wound infiltration with local anesthetics and spinal analgesia. The goal was to see which method reduces the need for morphine and lowers the chance of long-term pain. 186 adults having liver surgery took p…

This study looked at whether watching clips from classical Turkish comedy movies could help reduce pain and increase comfort in people who just had a liver transplant. 120 adult liver transplant recipients took part. Researchers measured their pain and comfort levels after watchi…

This study tested two different nerve block techniques to control pain after hip fracture surgery. 96 adults with hip fractures received either a PENG block plus a lateral femoral cutaneous nerve block, or a supra-inguinal fascia iliaca compartment block. The goal was to see whic…

This study tested whether giving ketamine and dexamethasone during back surgery helps control pain and reduces the need for morphine afterward. 128 adults having lumbar fusion surgery took part. The goal was to see if these drugs could improve recovery and lessen side effects lik…

This study looked at two ways to manage pain after arthroscopic shoulder surgery. The standard nerve block can sometimes cause temporary diaphragm paralysis, making breathing harder. The new block targets different nerves and may avoid that problem. Researchers tested it in 60 ad…

This study tested two methods to control pain after total knee replacement: a nerve block plus an injection around the knee, versus the injection alone. 174 adults who had knee surgery took part. The goal was to see which approach provides better pain relief and helps patients us…

This study tested two methods to control pain after gallbladder removal surgery: a nerve block near the ribs versus numbing the surgical cuts. Sixty adults took part to see which approach reduced pain and the need for strong painkillers like morphine in the first 24 hours. The go…

This study tested whether a special nerve block (RIB block) could reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy, a common weight-loss surgery. Fifty-six adults with severe obesity were randomly assigned to receive either the nerve block plu…

This study tested whether injecting numbing medicine around, rather than directly into, the nerve root could reduce severe rebound pain after shoulder surgery. Rebound pain is a short but intense pain that can happen as the nerve block wears off. The trial involved 85 adults and …

This study tested whether ketamine or lidocaine works better for pain after laparoscopic gallbladder removal. 76 adults were randomly assigned to receive one of the two drugs during surgery. Pain levels were checked at 1, 6, 12, and 24 hours after the operation. The goal was to f…

This study tested a nerve-freezing technique (cryoanalgesia) during robot-assisted lung surgery to see if it reduces pain afterward. 33 adults having lung surgery were randomly assigned to receive the nerve block or not. Researchers measured pain scores and pain medication use fo…

This study tested whether adding hyaluronidase (an enzyme that helps fluids spread) to a standard numbing medicine could improve pain relief after cesarean section. 114 women received an ultrasound-guided abdominal wall block with either plain bupivacaine or bupivacaine plus one …

This study looked at whether applying cold (cryotherapy) during a pulpotomy or root canal reduces pain and improves quality of life for people with deep cavities. 144 adults with deep decay in a molar were randomly assigned to get standard treatment with or without cryotherapy. T…

This study tested whether adding morphine to the standard spinal anesthetic (bupivacaine) could provide longer pain relief for people having hernia repair surgery. Fifty adults were randomly assigned to receive either the morphine combination or bupivacaine alone. The main goal w…

This study tested four ways of conditioning the carbon dioxide gas used during laparoscopic (keyhole) womb surgery. The goal was to see if warming, moistening, or adding numbing medicine to the gas could prevent a drop in body temperature and reduce pain after surgery. 248 women …

This study looked at whether listening to local music can lower pain and boost comfort in patients who had laparoscopic abdominal surgery. 120 adults from Turkey and Iran took part. Researchers measured pain and comfort levels to see if music made a difference.

This study tested two different numbing techniques for pain after video-assisted lung surgery. 176 adults received either an intercostal block with long-acting liposomal bupivacaine or a paravertebral block with standard bupivacaine. The main goal was to see which method reduced …

This study tested whether injecting a numbing medicine (ropivacaine) into the belly and around certain nerves before laparoscopic fibroid surgery could lower pain after the operation. 207 women took part, and researchers measured their pain levels and how quickly they could get u…

This study looked at using non-opioid pain medicines to manage pain after elective lower back surgery. The goal was to reduce pain and avoid opioid side effects like nausea and breathing problems. 75 adults having lumbar disc surgery took part. Researchers measured how many patie…

This study tested whether freezing certain nerves in the chest (cryoablation) can reduce pain and the need for strong painkillers after minimally invasive mitral valve surgery. Thirty adults took part, and the goal was to gather early data for a larger trial. The approach aims to…

This study looked at whether special nerve blocks (PECS II, parasternal, and serratus plane blocks) can reduce pain after minimally invasive heart surgery (MIDCAB). Researchers reviewed records of 88 adults who had this surgery, comparing those who received the blocks to those wh…

This study tested three different numbing methods to reduce pain after chest surgery (thoracoscopy). 155 adults were randomly assigned to receive a serratus plane block, a paravertebral block, or both together before surgery. The goal was to see which method works best for contro…

This study looked at how well people recover from gallbladder surgery when given pain medicine without opioids compared to standard opioid-based anesthesia. Fifty adults having planned laparoscopic gallbladder removal took part. The main goal was to measure recovery quality 24 ho…

This study aimed to improve pain treatment after outpatient surgery while reducing the need for opioid painkillers and their side effects. Over 900 adults having same-day or short-stay surgery took part. Researchers tested different anesthesia approaches to see which best control…

This study tested different doses of ketamine given through an IV to find a safe amount for women recovering from a cesarean delivery. The goal was to help with pain and prevent postpartum depression. Twelve women took part, and researchers found a dose that was well-tolerated wi…

This study looked at whether teaching women about pain before a planned hysterectomy could help lower their anxiety, stress, and pain after surgery. 62 women took part. The approach included a special pre-anesthesia checkup and pain education. The goal was to see if this extra pr…

This study compared two different nerve block techniques for pain relief after arthroscopic shoulder surgery. Researchers tested whether a newer combination nerve block could provide similar pain relief as the standard method while avoiding a common side effect that can temporari…

This study looked at 148 adults having teeth pulled to find out which simple, pre-surgery clues can predict how much pain they will feel afterward. Researchers tested a pain sensitivity questionnaire and other easy-to-measure traits. The goal is to help dentists personalize pain …

This study looked at how body mass index (BMI) influences pain levels after lumbar disc surgery when a nerve block is used for pain control. Researchers measured pain in 75 adults at different times after surgery. The goal was to see if higher BMI leads to more pain, which could …

This study looked at 36 people having breast cancer surgery to see how well different numbing techniques block pain. Researchers mapped the numb areas on the skin to find which method covers the surgical cut best. The goal is to help doctors choose the right numbing approach for …

This study looked at whether a person's genes can predict how well they respond to hypnosis for pain after surgery. Researchers analyzed DNA from 80 people who had already been in hypnosis trials. They tested a new, faster method to read pain-related genes and compared it to stan…

This study looked back at 128 children aged 2-18 who had ear, nose, or throat surgery. Researchers compared those who received standard opioid pain medicine during anesthesia to those who got an opioid-free approach. The goal was to see if avoiding opioids reduced confusion, agit…

This study looked at 120 adults having open heart surgery to see if an AI program could accurately judge whether nerve blocks were placed correctly. A computer and a doctor each rated ultrasound images of the blocks. The goal was to see if better block placement leads to less pai…

This study followed 2,500 adults having major surgery to learn why some people develop pain that lasts months afterward. Participants answered daily questions on their phone about their mood and physical state, and researchers collected medical history and pain sensitivity tests.…

This study looked at 120 adults having gallbladder surgery to see if a nerve block (ESP block) given before or after surgery changes heart electrical activity. The goal was to understand if the timing of the block affects heart risk. Results could help make anesthesia safer for p…

This study looked at whether measuring changes in the pupil of the eye (automated pupillometry) can help assess pain in intensive care patients who have delirium after surgery. Delirium makes it hard for patients to communicate pain. The study enrolled 49 patients and compared pu…

This study looked at whether specific brain wave signals during surgery can predict how much pain a person will feel afterward. Researchers monitored 57 adults having laparoscopic abdominal surgery. The goal is to find better ways to manage pain after operations.