Could a single pill before surgery cut opioid use after kidney stone treatment?
NCT ID NCT04122196
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive either pregabalin or a placebo about an hour before surgery. Researchers then measured pain scores and how much opioid medication patients used during recovery. The goal is to find a safer, non-narcotic way to manage post-surgery discomfort.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pregabalin (Lyrica)
What this could lead to
If it works, this could offer a simple way to reduce pain and the need for opioid painkillers after kidney stone surgery.
What could go wrong
This is a small, completed Phase 2/3 trial. The benefit may be modest, and pregabalin can cause side effects like dizziness or drowsiness.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for KIDNEY STONE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
University of Missouri-Columbia
Columbia, Missouri, 65212, United States