ADDICTION

This pilot study tests a personalized brain stimulation treatment for people with severe addiction who haven't been helped by other treatments. Ten participants will first undergo detox, then have temporary electrodes placed in their brain to map addiction-related areas, followed…

This study tests whether pairing a gentle electrical brain stimulation (tDCS) with computer-based cognitive training can help people with alcohol use disorder stay abstinent longer. About 40 participants who are already sober and in a residential program will receive the combined…

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study tests whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks helps people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 adults who completed a prior trial will receive either the drug or a pla…

This study tests whether semaglutide, a medication used for diabetes and weight loss, can safely reduce alcohol drinking in people with alcohol use disorder. About 67 adults will receive either semaglutide or a placebo shot weekly for 20 weeks, along with behavioral therapy and b…

This study tests a new way to prevent HIV among people who inject drugs and their friends or partners. Researchers will train some participants to become peer educators, teaching their social network about HIV testing, PrEP (a daily pill that prevents HIV), and treatment for opio…

This study looks at whether having regular motivational conversations after leaving the hospital can help people with alcohol use disorder stay away from alcohol for a full year. About 104 adults who have completed alcohol withdrawal in the hospital will take part. Half will get …

This study is testing whether a 12-week therapy program called ECCCLORE is practical and acceptable for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, stress, and relationships. Researchers will enroll …

This pilot study tests whether a non-invasive brain stimulation method called tDCS can reduce vaping in daily e-cigarette users. Forty adults who vape nicotine daily will receive either real or fake tDCS for 10 sessions over two weeks. Researchers will measure changes in vaping f…

This study follows 10,000 people seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological traits over several years using interviews and tests. The goal is to better understand addiction patterns and improve care.

This study compares 60 adults aged 18-45 who are addicted to smartphones, addicted to video games, or have neither habit. Researchers will measure pain, posture, hand strength, coordination, and reaction time to see how these addictions affect the upper body. The goal is to under…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 will have a brain scan and then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop reliable tools for future studies, not…