ADDICTION

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This study tested whether N-acetylcysteine (NAC), a widely available supplement, could help people with both alcohol use disorder and PTSD. 182 adults took either NAC or a placebo daily for 12 weeks, along with weekly therapy. Researchers measured changes in drinking habits, crav…

This study tested a breathing technique called Holotropic Breathwork to see if it helps people recover from addiction. 25 adults took part, either in a residential treatment program or living in the community. The goal was to see if the practice is safe, acceptable, and might red…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This pilot study tested whether adding protein supplements twice a day could reduce cravings in 28 people hospitalized for addiction. Participants spent one week with protein and one week without, rating their cravings on a simple scale. The goal was to see if a simple dietary ch…

This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving…

This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured…

This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive eith…

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This study used artificial intelligence to analyze personality and behavior data from 155 adults in residential treatment for substance use disorder. The goal was to find hidden subtypes of addiction that could lead to more personalized treatment. No treatment was given; the stud…

This study screened nearly 7,000 volunteers to find people who could take part in future research on drug addiction and its effects on the brain and body. Participants completed phone and in-person interviews, medical exams, and lab tests. No treatment or clinical care was provid…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study tested a training program called First Face for Mental Health, designed for staff at a Native American healing lodge. The training teaches people how to spot and respond to mental health crises and connect others to help. Researchers surveyed 92 trainees before, right …