CBD shows promise for opioid cravings and pain in early trial
NCT ID NCT05076370
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured safety, sedation, cognitive function, and effects on pain and cravings. The trial is complete, but results are not yet widely reported.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cannabidiol (CBD)
What this could lead to
If it works, this could point toward a safe, non-addictive option to help manage pain and reduce cravings in people with opioid use disorder.
What could go wrong
This was a very early, tiny study with only 7 people. It only tested single doses, not long-term use. Results may not apply to everyone, and side effects or lack of benefit are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Veteran Affairs Hospital
West Haven, Connecticut, 06516, United States