Could a depression drug help fight opioid addiction?

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults on stable buprenorphine therapy took part. The main focus was on safety, like heart rate and side effects, while also looking for early signs that the combination could improve treatment outcomes.