A new standard for pain pills after kidney stone surgery?

NCT ID NCT05353478

Ongoing Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests whether a standardized approach to prescribing opioid pain medication after percutaneous nephrolithotomy (PCNL), a surgery to remove kidney stones, can reduce the number of unused painkillers patients take home. Researchers will compare the usual prescribing habits with a set protocol to see if it leads to fewer leftover opioids and fewer unfilled or refilled prescriptions. The goal is to find a balance that manages pain effectively while avoiding overprescription.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A standardized opioid prescribing protocol
What this could lead to: If successful, this could establish a safer standard for prescribing painkillers after kidney stone surgery, reducing unused opioids and the risk of misuse.
What could go wrong: The trial is small and early, and results may not apply to all hospitals. Some patients might still need more pain relief than the standard plan provides.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY STONE

Contacts and locations

Locations

Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States

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