Spinach smoothie study reveals immune cell energy secrets

NCT ID NCT03877276

Ongoing Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how oxalate, a compound found in spinach, affects the energy use of white blood cells in healthy adults. Researchers will give participants a spinach smoothie and measure changes in immune cell function over five hours. The goal is to better understand how diet might influence kidney stone formation. The study involves 82 healthy adults aged 18 to 70.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dietary oxalate from spinach smoothie
What this could lead to: If successful, this study could reveal how oxalate-rich foods influence immune cell function, potentially guiding dietary advice for kidney stone prevention.
What could go wrong: This is a small, early-stage observational study with only 82 participants, so results may not apply broadly. It measures short-term cellular changes, not long-term health outcomes.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY STONE

Contacts and locations

Locations

University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States

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