Could your diet trigger kidney stones by changing your immune system?

NCT ID NCT04051346

Completed Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how eating high or low amounts of oxalate (a natural compound in many foods) affects urine crystals and immune cells in healthy adults. Fourteen participants followed two controlled diets to see if oxalate changes crystal formation and immune function. The goal is to better understand how diet might lead to kidney stones.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Low Oxalate Diet and High Oxalate Diet
What this could lead to: If successful, this could reveal how diet influences the immune system's role in kidney stone formation, pointing toward future prevention strategies.
What could go wrong: This is a small, early-stage study with only 14 healthy participants, not patients. Results may not apply to people with kidney stones or other conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY STONE

Contacts and locations

Locations

University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States

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