New anesthesia cocktail aims to cut opioids and boost recovery after surgery

NCT ID NCT06985069

Completed Symptom relief Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested whether a combination of four non-opioid drugs (magnesium, dexmedetomidine, ketamine, and lidocaine) given during major surgery could improve patient recovery compared to standard opioid-only anesthesia. 240 adults undergoing planned major surgery were randomly assigned to one of the two approaches. The main goal was to measure patient satisfaction and recovery quality using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Multimodal anesthesia (magnesium, dexmedetomidine, ketamine, lidocaine)
What this could lead to: If it works, this approach could reduce opioid use and improve patient satisfaction after major surgery.
What could go wrong: This is a single-center study with 240 participants, so results may not apply to all hospitals or surgeries. The combination of drugs may also cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opioid abuse Pain, Postoperative Postoperative Complications Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE PAIN, POSTOPERATIVE POSTOPERATIVE COMPLICATIONS POSTOPERATIVE NAUSEA

Contacts and locations

Locations

Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital

Bern, 3010, Switzerland

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