Ultra-Low fentanyl test may reveal hidden pain risk

NCT ID NCT00454259

Completed Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a very small dose of fentanyl can reveal how sensitive a person is to pain and whether they might develop worse pain after surgery. Researchers will give healthy volunteers either fentanyl or a placebo and measure their pain threshold using a mechanical stimulator. The goal is to see if this simple test could one day help doctors identify patients who need extra pain management before surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fentanyl
What this could lead to: If successful, this could lead to a simple test to predict which patients are at higher risk for severe pain after surgery.
What could go wrong: This is a small, early-phase study in healthy volunteers, not patients. The test may not work in real-world surgical settings or predict pain accurately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN, POSTOPERATIVE

Contacts and locations

Locations

CHU de Bordeaux Département d'Anesthésie-Réanimation II

Pessac, Hôpital Cardiologique, 33604, France

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