New pain block could reduce opioid use after lung surgery
NCT ID NCT04864210
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compared two ways to manage pain after video-assisted lung surgery: an intercostal nerve block using liposomal bupivacaine and a paravertebral block using plain bupivacaine. 176 adults undergoing VATS were enrolled. The main goal was to see how many patients needed opioid painkillers in the first 48 hours after surgery. The results could help doctors choose the best pain relief method to reduce opioid use and improve recovery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal bupivacaine and plain bupivacaine
What this could lead to
If one method works better, it could lead to better pain control and less opioid use after lung surgery.
What could go wrong
This is a small, completed Phase 2 trial, so results may not apply to all patients. The liposomal bupivacaine is not FDA-approved for this use, and individual responses vary.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Iowa
Iowa City, Iowa, 52242, United States