Simple heparin dressing may reduce scars and pain after skin grafts

NCT ID NCT07196358

Completed Disease control Sponsor: Dr. Ruth K.M. Pfau Civil Hospital, Karachi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a dressing soaked in heparin, a blood-thinning medicine, can prevent thick, raised scars and reduce pain at the site where skin is taken for a graft. 400 patients each had one donor site treated with standard care and the other with a heparin dressing. The researchers compared scarring and pain over three months to see if this low-cost method improves healing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: heparin (topical solution)
What this could lead to: If it works, this could offer a simple, low-cost way to reduce scarring and pain after skin graft surgery.
What could go wrong: This is a completed study, but results are not yet widely confirmed. The effect may be modest, and heparin can cause allergic reactions in some people.

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Conditions

The condition(s) this trial relates to.

Cicatrix, Hypertrophic injury Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTROPHIC SCARRING PAIN, POSTOPERATIVE WOUND HEALING

Contacts and locations

Locations

Plastic & Reconstructive Surgery Department, Ruth Pfau Civil Hospita

Karachi, Sindh, Pakistan

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