Can a Blood-Based clot improve mouth healing in people with obesity?
NCT ID NCT07756112
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study looks at how body weight affects healing after gum graft surgery, where tissue is taken from the roof of the mouth. Researchers will compare two wound treatments: a standard collagen plug and a clot made from the patient's own blood, called platelet-rich fibrin (PRF). Participants will be grouped by weight (obese or normal) and randomly assigned to receive one of the two treatments. The goal is to see if PRF works as well as the standard care and to understand how obesity influences the healing process.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Platelet-rich fibrin (PRF) clot, a healing material made from the participant's own blood, compared to the standard-of-care collagen plug.
- What this could lead to
- If PRF proves as effective as collagen plugs, it could offer a natural, personalized option to improve healing after gum grafts, especially for people with obesity.
- What could go wrong
- This is an early-stage study with a small number of participants, and results may not apply to everyone. Healing outcomes can vary widely, and PRF may not show a clear benefit over the standard treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Iowa College of Dentistry and Dental Clinics
Iowa City, Iowa, 52242, United States
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