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Can a One-Two punch tame overgrown wound tissue?

NCT ID NCT06681194

Disease control Sponsor: Francesco Egro Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests three ways to treat hypergranulation tissue—excess flesh that can slow healing in traumatic wounds. Adults with non-infected wounds will receive either silver nitrate, triamcinolone, or both treatments in sequence. The goal is to see which approach best reduces the overgrown tissue and improves scar quality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
silver nitrate, triamcinolone, or both in succession
What this could lead to
If successful, this could establish a standard treatment for hypergranulation tissue in traumatic wounds, improving healing and reducing scarring.
What could go wrong
This is a small, early-phase trial, so results may not apply broadly. Treatments may cause irritation or allergic reactions, and the combination approach might not outperform single agents.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Started

Mar 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must be 18 years or older. * Patients must be admitted to the institution with non-infected, traumatic wounds exhibiting hypergranulation tissue. * Patients must provide consent to participate in the study. * Eligible wounds include superficial or partial-thickness wounds. * Wounds will be categorized based on size and depth, with variations controlled for in the statistical analysis. Exclusion Criteria: * Patients with known allergies or contraindications to silver nitrate or triamcinolone. * Patients with wounds that do not exhibit hypergranulation tissue. * Patients with wounds not primarily due to traumatic injury (e.g., surgical wounds, pressure ulcers). * Full-thickness, infected, or complex wounds will be excluded, as these may require different management strategies.

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Granulation tissue Wound healing

Contacts and locations

Locations

  • UPMC Mercy Hospital

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

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