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Could a simple gel speed up gum graft recovery?

NCT ID NCT07708051

Knowledge-focused Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks at whether a gel made from polynucleotides and hyaluronic acid can help gum tissue heal better after a graft is taken from the roof of the mouth. Fifteen adults with gum recession will have grafts taken from both sides of their palate in two separate surgeries, nine weeks apart. One side gets the gel; the other does not. Researchers will compare tissue samples under a microscope to see if the gel improves healing and tissue quality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a polynucleotide and hyaluronic acid gel (Regenfast) applied topically to the palate after graft harvesting
What this could lead to
If the gel improves tissue quality, it could lead to faster or better healing after gum graft procedures.
What could go wrong
This is a very small, early study (15 people) looking at tissue samples, not clinical outcomes. The gel may not show any benefit over natural healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 60 years * Good general systemic health * Presence of multiple bilateral gingival recessions with indication for root coverage Exclusion Criteria: * Smoking of any intensity * Pregnancy or lactation * Oral lesions or alterations in the palatal mucosa * Previous history of graft harvesting from the donor area * Continuous use of medications that interfere with the inflammatory response, such as corticosteroids or immunosuppressants * Autoimmune diseases, coagulation disorders, or other systemic conditions affecting wound healing

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Conditions

The condition(s) this trial relates to.

gingival recession injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession, generalized Gingival recession, localized Palate; wound Wound healing

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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