New combo pill aims to beat Post-Surgery pain

NCT ID NCT04641338

Completed Symptom relief Sponsor: Brazilian Clinical Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed Phase 3 trial tested whether a fixed-dose combination of dipyrone and codeine provides better pain relief than either drug alone after open pelvic-abdominal surgery. 491 adults with moderate to severe pain were enrolled. The main goal was to see if more people achieved at least 50% pain relief within 6 hours with the combo pill.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dipyrone and codeine combination
What this could lead to: If successful, this could provide a more effective, single-pill option for managing moderate to severe pain after major surgery.
What could go wrong: This is a completed Phase 3 trial, but results may not apply to all surgeries or pain types. Side effects like nausea, dizziness, or constipation are possible with codeine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN, POSTOPERATIVE

Contacts and locations

Locations

Associação Hospital de Caridade Ijuí - Núcleo de Ensino e Pesquisa

Ijuí, Rio Grande do Sul, Brazil
Hospital Universitário São Francisco na Providência de Deus

Bragança Paulista, São Paulo, Brazil
Santa Casa de Misericórdia de Votuporanga

Votuporanga, São Paulo, Brazil

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