New combo pill aims to beat Post-Surgery pain
NCT ID NCT04641338
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This completed Phase 3 trial tested whether a fixed-dose combination of dipyrone and codeine provides better pain relief than either drug alone after open pelvic-abdominal surgery. 491 adults with moderate to severe pain were enrolled. The main goal was to see if more people achieved at least 50% pain relief within 6 hours with the combo pill.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dipyrone and codeine combination
What this could lead to
If successful, this could provide a more effective, single-pill option for managing moderate to severe pain after major surgery.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all surgeries or pain types. Side effects like nausea, dizziness, or constipation are possible with codeine.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Associação Hospital de Caridade Ijuí - Núcleo de Ensino e Pesquisa
Ijuí, Rio Grande do Sul, Brazil
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Hospital Universitário São Francisco na Providência de Deus
Bragança Paulista, São Paulo, Brazil
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Santa Casa de Misericórdia de Votuporanga
Votuporanga, São Paulo, Brazil