PAIN, POSTOPERATIVE

This study tests two ways to numb the arm for wrist fracture surgery in people at high risk for severe pain. One method uses a long-acting numbing drug (liposomal bupivacaine) plus regular bupivacaine, and the other uses a steroid (dexamethasone) plus regular bupivacaine. The goa…

This study tests whether taking omega-3 fatty acids before and after gallbladder surgery can lower the amount of morphine needed for pain. Forty adults will receive either omega-3 supplements or a placebo, plus a small dose of morphine after surgery. Researchers will measure tota…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This study compares two types of nerve blocks for pain control after hip surgery: the PENG block and the femoral nerve block. Researchers will measure pain levels and leg muscle strength in 100 adults aged 40 and older. The goal is to find which method provides better pain relief…

This study tests whether adding high-intensity laser therapy to standard physical therapy helps reduce pain and improve movement after knee replacement surgery. About 46 adults aged 50 to 80 will be randomly assigned to receive either real laser therapy or a sham treatment alongs…

This study tests whether adding suzetrigine to standard pain management helps more women stay completely opioid-free for the first 72 hours after a C-section. About 90 women having scheduled or unscheduled C-sections will receive either suzetrigine or a placebo, along with usual …

This study compares a low volume of the painkiller bupivacaine to the standard volume for a nerve block after gallbladder surgery. The goal is to see if the lower dose controls pain just as well while reducing the risk of side effects. About 96 adults having planned gallbladder s…

This study tests whether giving a single dose of methadone during spine surgery can improve pain control and reduce the need for other opioids afterward. About 30 adults having elective spine surgery will be randomly assigned to receive either methadone or standard pain medicine.…

This study tests whether a new form of the anti-inflammatory drug dexamethasone (called dexamethasone palmitate) can prevent moderate-to-severe pain after surgery better than the standard version. About 446 adults having various surgeries will receive the drug before their operat…

This study compares two ultrasound-guided pain blocks for people having lumbar back surgery. Both blocks use numbing medicine to reduce pain after the operation. The goal is to see which block lowers the need for opioid painkillers and improves recovery. Eighty adults aged 18 to …

This Phase 2 trial tests whether BL1332 eye drops can reduce pain after PRK laser eye surgery. About 123 adults will receive either a low or high dose of the drops or a placebo, applied five times a day. The study is double-masked, meaning neither patients nor doctors know who ge…

This study tests a new painkiller called tegileridine in 152 adults having abdominal surgery. The goal is to see if it helps the bowels start working again faster than the standard drug morphine. Participants will use a patient-controlled pain pump for up to 72 hours after surger…

This study tests whether using ultrasound to guide a scalp nerve block provides better pain control after brain tumor surgery in children compared to the traditional method. About 74 children having surgery on one side of the brain will be randomly assigned to receive either an u…

This study tests whether an extra nerve block given during weight-loss surgery can lower pain, nausea, and the need for painkillers in the first three days after surgery. About 200 adults having gastric bypass or sleeve gastrectomy will be randomly assigned to get either standard…

This study tests whether a warm foot bath on the night of abdominal surgery can reduce pain, improve sleep, and increase comfort. Around 96 adults will be randomly assigned to receive a foot bath or standard care. Researchers will measure pain levels and sleep quality using simpl…

This pilot study tests whether a home-based brain stimulation device (tDCS) can help people recover better after total knee replacement. About 70 adults scheduled for knee surgery will use the device before and after their operation. The main goal is to see if the study is feasib…

This study will compare two devices that blow gas into the belly during laparoscopic sleeve gastrectomy (a weight-loss surgery). The goal is to see if one device causes less pain after surgery than the other. About 74 adults aged 22 to 65 having planned sleeve gastrectomy will be…

This study compares two devices used during robotic gastric sleeve surgery to see which causes less shoulder, neck, and chest pain afterward. About 74 adults having non-emergency sleeve gastrectomy will be randomly assigned to receive either the AirSeal or DV5 insufflation system…

This study tests whether a single injection of the numbing drug ropivacaine around nerves can reduce pain and the need for narcotic pain pills in children and teens after ACL knee surgery. About 160 participants aged 13 and older will either receive the nerve block or not during …

This study uses surveys to understand how caregivers, surgeons, and anesthesiologists feel about using methadone for pain in children having outpatient surgery. Researchers want to see if factors like neighborhood, language, or race affect these views. The goal is to gather infor…