PAIN, POSTOPERATIVE

This study compares two ultrasound-guided nerve blocks—modified thoracolumbar interfascial plane block and quadro-iliac plane block—for pain relief after lower back surgery. About 80 adults undergoing elective lumbar instrumentation will receive one of the two blocks. The goal is…

This study tests whether a drug called suzetrigine can help women who have a C-section avoid taking opioid painkillers. About 90 women will receive either suzetrigine or a placebo along with standard pain relief. The main goal is to see how many stay completely opioid-free for th…

This study tests whether adding high-intensity laser therapy to standard physical therapy helps people recover faster and with less pain after knee replacement surgery. About 46 adults aged 50 to 80 will be split into two groups: one gets real laser therapy plus rehab, the other …

This study tests whether a new eye drop called BL1332 can reduce pain after PRK laser eye surgery. About 123 adults aged 18 to 58 will receive either the active drop or a placebo. The goal is to see if the drop safely lowers pain scores in the first days after surgery.

This study tests whether an extra nerve block given during weight-loss surgery can lower pain, nausea, and the need for painkillers in the first three days after the operation. About 200 adults having gastric bypass or sleeve gastrectomy will be randomly assigned to receive eithe…

This study compares a lower volume of the numbing drug bupivacaine to the standard volume for a pain block after gallbladder surgery. The goal is to see if the lower dose works just as well while reducing the risk of side effects. About 96 adults having planned gallbladder surger…

This study tests if using a safe, non-invasive brain stimulation device at home before and after knee replacement surgery can help manage pain and lower the risk of long-term pain. About 70 adults scheduled for knee replacement will use the device or a sham version. The main goal…

This study looks at whether giving patients a foot bath after abdominal surgery can help reduce pain, improve sleep quality, and increase comfort. About 96 adults who have just had surgery will be randomly assigned to receive a foot bath or standard care. The goal is to see if th…

This study compares two ways of numbing the scalp to control pain after brain tumor surgery in children. The new method uses ultrasound to guide the numbing medicine, which may be safer and more accurate than the traditional approach of feeling for landmarks. The trial will inclu…

This study looks at whether a single shot of a numbing medicine (ropivacaine) near the nerves can lower pain and the need for narcotic pain pills in children after ACL knee surgery. About 160 kids aged 13 and older will be randomly assigned to get either the nerve block or no blo…

This study tests whether a new version of the anti-inflammatory drug dexamethasone, called dexamethasone palmitate, can better prevent moderate-to-severe pain after surgery compared to the standard form. About 446 adults aged 18-65 having various surgeries will receive the drug b…

This study tests two different machines that pump gas into the belly during laparoscopic sleeve gastrectomy (a weight-loss surgery). The goal is to see if one device causes less pain in the shoulder, neck, chest, and belly after surgery. About 74 adults aged 22 to 65 having plann…

This study tests whether giving a single dose of methadone during spine surgery can improve pain control and reduce the need for other opioids. About 30 adults having elective spine surgery will be randomly assigned to receive either standard pain medicines or a single dose of me…

This study compares two devices that inflate the belly during robotic gastric sleeve surgery. The goal is to see which device causes less shoulder, neck, and chest pain after the operation. About 74 adults having planned sleeve gastrectomy will take part. The results could help i…

This study compares two methods to control pain after total knee replacement. One method uses two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus numbing medicine injected by the surgeon. The goal is to see which approach provides better pain re…

This study tests whether a new pain medicine called tegileridine helps the bowels work again sooner after abdominal surgery compared to morphine. About 152 adults having planned abdominal surgery will use a pain pump for up to 72 hours after their operation. The main goal is to s…

This study will look at 100 adults having nose surgery to see if their smartphone habits affect how much pain they feel and how much pain medicine they need afterward. Researchers will measure pain levels and painkiller use in the first 24 hours after surgery. The goal is to unde…

This study uses surveys to understand how parents, surgeons, and anesthesiologists feel about using methadone for pain after children's outpatient surgery. Researchers want to see if views differ based on where families live, language, or race. The goal is to gather information, …