Long-Lasting painkiller may cut opioid use after nose jobs
NCT ID NCT07689162
First seen Jul 08, 2026 · Last updated Jul 10, 2026 · Updated 2 times
Summary
This trial tests whether a long-acting form of the painkiller bupivacaine (liposomal bupivacaine) works better than the standard version for controlling pain after rhinoplasty (nose surgery). Adults undergoing open rhinoplasty for any reason—medical or cosmetic—will receive one of the two drugs during surgery. Researchers will measure total opioid use and pain levels over the first three days to see which approach leads to less discomfort and fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Liposomal bupivacaine (Exparel) and standard bupivacaine (Marcaine)
- What this could lead to
- If liposomal bupivacaine works better, it could reduce opioid use and improve recovery after rhinoplasty.
- What could go wrong
- This is a small Phase 2 trial, so results may not apply broadly. Liposomal bupivacaine is more expensive and may not prove superior.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Washington University
St Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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