Two nerve blocks go head to head for breast surgery pain
NCT ID NCT06781346
First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time
Summary
Researchers compare two ultrasound-guided nerve blocks to see which better controls pain after breast cancer surgery. Adults scheduled for mastectomy or breast-conserving surgery receive either a rhomboid intercostal block or a thoracic paravertebral block. The trial measures how much fentanyl patients need in the first 24 hours after surgery, along with pain scores and side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- rhomboid intercostal block and thoracic paravertebral block, two ultrasound-guided nerve block procedures
- What this could lead to
- If the rhomboid intercostal block works as well as the thoracic paravertebral block, it could offer a safer way to control pain after breast cancer surgery, with less risk of puncturing the lung lining.
- What could go wrong
- The trial may show the two blocks are not equally effective, or that one causes more side effects. Results from this single hospital may not apply to all patients or surgical settings.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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180 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients 18 years of age or older . * American Society of Anesthesiologists (ASA) II-lll Scheduled for elective breast surgery for modified radical mastectomy, simple mastectomy, breast conservative surgery. Exclusion Criteria: * Patient refusal. * Significant renal, hepatic and cardiovascular diseases. * History of allergy to one of the study drugs. * Any contraindication to regional anesthesia such as local infection or bleeding disorders. * Chronic opioid use, history of chronic pain and cognitive disorders. * Emergent surgeries
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fayoum university Hospital
El Fayoum Qesm, Faiyum Gove, 63514, Egypt
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Other studies related to the condition(s) this trial covers.
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