OSTEOARTHRITIS

This study tested a treatment called CHONDRON, which uses a patient's own cartilage cells grown in a lab to repair knee damage. It involved 22 people with cartilage defects from arthritis or injury. The main goal was to see if the treatment reduced pain and improved knee function…

This study tested whether a single injection of stem cells taken from a patient's own belly fat could help people with mild to moderate knee osteoarthritis that hasn't improved with other treatments. About 100 adults received either a low dose, a high dose, or a placebo injection…

This study compared four types of knee replacement implants in 218 adults with knee osteoarthritis. The goal was to see which design helped people forget they had an artificial joint, measured by the Forgotten Joint Score. Results will help surgeons choose the best option for the…

This study tested a new injection treatment for wrist osteoarthritis in 12 adults who had not improved with standard care. The treatment uses a mixture of the patient's own fat cells and platelet-rich plasma, injected into the wrist joint. The goal was to see if this approach is …

This study tested an experimental drug called LNA043, given as a shot directly into the knee, to see if it can help regrow cartilage in people with knee cartilage damage or osteoarthritis. About 142 adults took part, receiving either the drug or a placebo. The main goals were to …

This study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease too…

This study compared two types of knee implants (Vanguard Cruciate Retaining and AGC Total Condylar) in 150 people with arthritis needing knee replacement. The goal was to see which implant provides better pain relief and function. Participants were followed for several years to t…

This study tested a treatment called Chondron, which uses a patient's own cartilage cells grown in a lab and then placed into the knee during surgery. Ten people with knee cartilage damage from osteoarthritis or injury took part. The main goal was to see if the treatment reduced …

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, with a second dose 12 weeks later. Researchers monitored side…

This study looked at how well a cementless hip implant (POLARSTEM) works in people with osteoarthritis. 218 patients were followed for up to 10 years after surgery. The main goal was to see how long the implant lasts without needing to be replaced, and how well patients could mov…

This study tested whether using vancomycin powder and a diluted iodine wash during hip or knee replacement surgery can prevent serious infections in high-risk patients. Over 2,000 adults with conditions like obesity or smoking habits took part. The goal was to see if these simple…

This study looked at whether a genicular nerve block (an injection near the knee nerves) can reduce pain and improve quality of life and joint position sense in people with chronic knee osteoarthritis. Forty adults aged 55-75 with moderate knee osteoarthritis took part. The goal …

This study looked at whether a specific type of muscle training (eccentric exercise) can improve walking ability in people with knee osteoarthritis. 40 adults aged 40-85 with knee arthritis took part. The main goal was to see if this exercise program helps them walk farther in a …

This study tested a single injection of EVI-01 in 120 adults with painful knee osteoarthritis. Participants received one of two doses or a standard treatment to see which worked best for easing pain and stiffness. The goal was to find the safest and most effective dose for sympto…

This study tested a device that sends mild electrical pulses to a nerve in the ear, aiming to reduce pain and inflammation in people with a severe type of hand arthritis called erosive osteoarthritis. 148 adults with painful, swollen finger joints used either the active device or…

This study tested whether a gel injection (polyacrylamide hydrogel) into the knee joint can reduce pain and improve daily function in people with knee osteoarthritis. 387 patients (593 knees) were treated across three medical centers. Results showed that the injection helped ease…

This study followed 260 people who received a Medacta GMK Sphere knee replacement for osteoarthritis. The main goal was to see how well the artificial knee feels like a natural part of the body, using a "Forgotten Knee Score" at 2 and 5 years after surgery. Researchers also measu…

This study tested a single injection of the drug RTX-GRT7039 in 466 adults with knee osteoarthritis pain that wasn't helped by standard treatments. The goal was to see if the injection reduces pain better than a placebo (fake shot). Researchers measured pain changes at 12 and 26 …

This study tested whether a single injection of type I collagen into the knee joint can reduce pain in people with knee problems like arthritis or injury. Two hundred adults received either the collagen injection or a placebo, and their pain was measured after 24 weeks. The goal …

This study looked at whether following special hip precautions after a total hip replacement helps prevent the hip from dislocating. Over 1,100 patients were randomly assigned to either follow precautions or not. The goal was to see if precautions made a difference in dislocation…

This study looked at whether a 4-week course of self-administered oxytocin nasal spray can reduce pain and improve daily function in older adults with knee osteoarthritis. Researchers compared the spray to a placebo in 83 participants to see if it works and to understand how it a…

This study tested whether an 8-week mindfulness program (MBSR) can reduce pain and improve daily function in 40 adults with hip or knee osteoarthritis. Participants were randomly assigned to either the mindfulness program or usual care. The main goal was to see if mindfulness tra…

This early-stage study tested a new medicine called APPA-1 in 40 healthy volunteers and people with osteoarthritis. The main goal was to see if it is safe and how the body processes it. Researchers also looked at how food and gender affect the drug. This is a first step toward fi…

This study tested the safety of an experimental injection called RTX-GRT7039 for people with moderate to severe knee pain from osteoarthritis. 714 adults who did not get enough relief from standard treatments received one or two injections. The main goal was to check for side eff…

This study tested whether an injection made from a person's own blood (called A2MRP) is safe and can reduce pain in people with moderate knee osteoarthritis. Twenty adults aged 18 to 65 with knee arthritis received the injection. Researchers tracked side effects and used pain que…

This study tested whether a daily plant protein supplement (Nutrilite All-Plant Protein Booster) could improve muscle function and ease arthritis symptoms in 139 adults aged 50 to 70 with mild to moderate sarcopenia (muscle loss) and osteoarthritis. Participants took the suppleme…

This study tested whether a fixed-dose combination of etoricoxib and diacerein works better than another combination (meloxicam and diacerein) for reducing pain in adults with knee or hip osteoarthritis. 123 participants took the assigned drug daily for 60 days and reported their…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, or lupus. Participants were followed for up to one year to see if the program helped reduce pain and improve physical function like walking and chair stands. T…

This study tested a single injection of a new drug (SAR446959) in the knees of 32 adults aged 45-65 with osteoarthritis. The main goal was to check safety and side effects, not to prove it works. Participants were followed for about 28 weeks to monitor any reactions and how the d…

This study looked at two ways to manage pain after knee replacement surgery: a shot around the knee joint (periarticular injection) and a nerve block in the thigh (adductor canal block). The goal was to see which method helps patients recover better and feel less pain. Sixty adul…

This study tested whether an experimental drug called RTX-GRT7039, given as a shot into the knee, can reduce pain in people with knee osteoarthritis who haven't gotten enough relief from standard treatments. About 469 adults took part. The goal was to see if the injection improve…

This study tested three different types of injections made from a patient's own blood platelets to see which works best for jaw arthritis. It involved 42 adults with osteoarthritis in their jaw joint. The goal was to see which injection reduced pain the most and helped people ope…

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned standard facts about the disease, while the other learned about how the brain and nerves process pain. Researchers measured whether the newer approach changed the body…

This study followed 225 people who had ACL knee surgery to see what factors lead to arthritis later. Researchers checked knee structure and function 2 and 10 years after surgery. The goal is to find ways to prevent arthritis after ACL injuries.

This study looked at over 288,000 people with hip or knee osteoarthritis to learn how factors like education, marital status, and other health conditions affect their long-term outcomes. Participants received standard care including exercise, education, and weight loss advice. Th…

This study looked at how mind-body exercise (like yoga or tai chi) compares to a wellness education program in changing gut bacteria in people with osteoarthritis. 72 adults aged 55 and older with knee or hip arthritis took part. The goal was to gather information for a larger fu…

This study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used exams, imaging, and surveys to track pain, inflammation, and joint changes. The goal was to learn how the disease progresses and what factors predict outcomes, not to test a new treatment.

This study checked if a three-week program of balneotherapy (mineral baths) changes heart function in 44 adults with osteoarthritis. Participants had heart ultrasounds before and after the baths. The goal was to see if the therapy affects how the heart pumps and relaxes, not to t…

This study followed 432 people who had ACL reconstruction surgery to learn why some develop knee arthritis years later. Researchers measured knee joint space on X-rays at 2 and 10 years after surgery. The goal is to identify which injuries, repairs, or patient traits raise arthri…

This study tested whether changes in pupil size can reliably measure acute pain. Researchers gave short, painful heat pulses to 20 adults with hip or knee arthritis and measured how their pupils reacted. The goal was to see if pupil response could be a trustworthy, objective pain…

This study looked at how well people with ankle arthritis functioned after surgery. Researchers followed 368 patients for up to 12 years, using surveys and walking tests to measure their progress. The goal was to understand which surgical approaches lead to better long-term outco…

This study examined how the COVID-19 pandemic affected primary care for people with chronic conditions like diabetes, heart failure, and depression in Canada. Researchers analyzed health records from nearly 920,000 adults to see changes in doctor visits, tests, and treatments. Th…

This study tested a training program for rheumatologists to help them break unconscious bias habits when treating Black and low-income patients. 201 patients and their doctors took part. The goal was to see if the training led to better quality care, communication, and patient tr…

This study looked at 120 adults over 40 who had knee replacement surgery for osteoarthritis. Researchers compared four different types of knee implants to see how they affected walking, stair climbing, strength, and balance over two years. The goal was to learn which implant help…

This study looked at 40 people who needed a hip replacement due to arthritis, hip damage, or other conditions. All had surgery through a small front incision. The goal was to see if two different implant designs (AMIStem vs Quadra) led to similar bone density changes around the i…

This study created easy-to-use questionnaires for the shoulder, knee, and ankle. The goal was to help people decide if they need to see an orthopedic specialist. Researchers collected answers from 150 adults who already had appointments for joint problems. They will use the data …