OSTEOARTHRITIS

This study compared four different knee replacement implants to see which ones help patients recover strength, balance, and mobility best after surgery. Researchers followed 120 adults with knee arthritis for two years, measuring how well they could walk, climb stairs, and stand …

This study tested whether strict movement restrictions after hip replacement surgery are necessary to prevent dislocation. Over 1,100 patients with hip arthritis were randomly assigned to follow the usual precautions or not. Researchers measured dislocation rates, how quickly pat…

This study compared two different thigh bone parts used in hip replacement surgery. Researchers wanted to see if one part was better at preserving the patient's natural bone density around the implant. They also measured how well patients could walk and move after surgery to see …

This study tested whether a single injection of a patient's own stem cells, taken from their body fat, could help treat painful knee arthritis. It compared two different doses of these cells against a placebo injection in 100 people whose knee pain hadn't improved with standard t…

This study followed 218 patients for up to 10 years to see how well a specific cementless hip implant (the POLARSTEM) works and lasts for people with severe osteoarthritis. Researchers tracked pain, mobility, and X-ray changes to measure the implant's performance and safety over …

This was the first study in people to test the safety of an experimental drug called SAR446959, injected directly into the knee joint. It involved 32 adults aged 45-65 with knee osteoarthritis. The main goal was to see if the injection was safe and how the body processed it, comp…

This study compared two types of knee replacement implants for people with severe arthritis. It tested whether a newer implant design (Vanguard) performed better than an older one (AGC) in terms of knee function and pain relief. The study involved 150 adults who needed a total kn…

This early-stage study tested whether an experimental drug called CYT-108 is safe when injected into the knee joint of people with mild to moderate osteoarthritis. Nineteen participants received either the drug or a placebo injection and were monitored for side effects over 26 we…

This study tested whether using antibiotic powder and an antiseptic wash during joint replacement surgery could prevent serious infections afterward. It involved over 2,100 patients at high risk for infection, such as those with diabetes, obesity, or who were having a second surg…

This large study investigated whether taking daily vitamin D or fish oil supplements could help prevent new autoimmune diseases, reduce body-wide inflammation, or lessen chronic knee pain. It involved over 25,000 U.S. adults without a prior history of cancer or heart disease. Res…

This small Mayo Clinic study tested whether an injection made from a patient's own processed blood plasma could safely reduce pain and improve function in people with moderate knee osteoarthritis. Twenty participants with ongoing knee pain received the injection and were followed…

This study tested if a specific 6-week muscle-strengthening program could help people with knee osteoarthritis walk better and feel less tired. Researchers compared two different types of exercise in 40 participants to see which was more effective for improving walking distance a…

This study followed patients who received a specific type of artificial knee replacement to see how well it worked over time. Researchers tracked 70 patients for up to 5 years after surgery to measure how much they could 'forget' their artificial joint during daily activities. Th…

This first-in-human study tested the safety of a new oral drug called APPA-1, which combines two plant-based compounds traditionally used for inflammation. It involved 40 healthy volunteers and people with osteoarthritis to see how the body processes the drug and if it is well-to…

This study looked back at 387 people with knee osteoarthritis who received a special gel injection into their knee joint. The goal was to see if the injection could reduce their pain and help them move better in daily life. Researchers measured pain and function before the inject…

This study tested whether repeated injections of an experimental drug called RTX-GRT7039 could safely reduce pain in adults with knee osteoarthritis. About 469 participants who still had significant pain despite standard treatments received either the drug or a placebo injection …

This study tested the safety of a new injection called RTX-GRT7039 for people with moderate to severe knee pain from osteoarthritis. It involved 714 adults whose standard pain treatments weren't working well enough. The main goal was to see how safe and tolerable the injections w…

This study tested whether a 6-week walking program delivered over the phone could help people with arthritis manage their symptoms. Researchers enrolled 267 adults with various forms of arthritis and randomly assigned them to start the program immediately or after a year. The pro…

This study compared two different pain control methods used after total knee replacement surgery. Researchers wanted to see which method—a combination of injections or a specific nerve block—helped patients recover better and feel less pain after their operation. They measured re…

This study tested three different types of injections made from a patient's own blood platelets to see which works best for jaw arthritis. It involved 42 adults with osteoarthritis of the jaw joint. The goal was to see which injection reduced pain the most and helped people open …

This study tested a single injection called EVI-01 to relieve pain and stiffness from knee osteoarthritis. It involved 120 adults with moderate to severe knee pain to find the most effective and safe dose. Researchers compared two different doses of EVI-01 against an existing act…

This study compared two ways of educating older adults with knee osteoarthritis about their pain. One group received standard education about joint disease, while another learned about the complex biology of pain itself. Researchers measured the body's physical stress responses, …

This study tested whether a nasal spray containing oxytocin, a natural hormone, could safely reduce pain and improve daily function in older adults with knee osteoarthritis. Over 80 participants used the spray or a placebo daily for four weeks. Researchers measured changes in pai…

This study tested whether a mindfulness training program could help people manage pain from hip or knee osteoarthritis. Forty participants with moderate to severe pain were randomly assigned to either the mindfulness course or a control group. Researchers measured changes in pain…

This large, completed Phase 3 trial tested whether a single injection into the knee joint could safely reduce pain for people with osteoarthritis. It compared the experimental injection, called RTX-GRT7039, against a placebo (a dummy injection) in 466 adults whose knee pain wasn'…

This study tested a non-invasive device that delivers mild electrical stimulation to the ear to see if it could reduce pain and inflammation in people with a severe, painful form of hand arthritis. For 12 weeks, 148 participants used either a real or a fake (sham) device to compa…

This study tested whether a daily plant protein powder could help improve two common age-related conditions: sarcopenia (muscle loss) and osteoarthritis (joint pain). For 12 weeks, 139 adults aged 50-70 with mild to moderate symptoms took either the protein powder or a look-alike…

This study followed 432 people for up to 10 years after they had surgery to repair a torn knee ligament (ACL). Researchers wanted to understand why some people develop painful knee arthritis years after this common surgery. They looked at factors from the original injury, the sur…

This study analyzed health records from over 75,000 Swedish patients with hip or knee osteoarthritis to learn more about their health and social factors. Researchers compared these patients to the general population to understand who does well with standard treatment (education a…

This study compared two common surgeries for severe ankle arthritis: fusion and joint replacement. Researchers followed 368 patients for up to 12 years after surgery, tracking their pain, mobility, and daily step counts. The goal was to understand which procedure provides better …

This study tested a brief training program for rheumatologists (arthritis doctors) to see if it could help them provide more equal, high-quality care to Black and lower-income patients. The training focused on getting doctors to see each patient as an individual, rather than rely…

This study followed 225 people for 10 years after ACL knee surgery. Researchers measured knee joint space and pain levels to understand what factors lead to osteoarthritis. The goal is to identify risks like smoking, weight, or specific injury details to help future patients.

This study aimed to better understand hand osteoarthritis by closely observing 300 patients over many years. Participants underwent detailed exams, scans, and questionnaires at the start and then again after 3 and 8 years. The goal was to learn what factors predict how the diseas…

This small, completed study explored whether mind-body exercise like Tai Chi changes gut bacteria in people with knee osteoarthritis, and if those changes relate to pain and stiffness. Researchers compared 12 weeks of Tai Chi to a wellness education program in 72 participants age…

This study looked at whether thermal bath therapy (balneotherapy) affects heart function in people with osteoarthritis. Researchers measured heart activity using ultrasound in 44 adult and elderly patients before and after a 3-week program of warm water immersion. The goal was to…

This study looked back at the health records of nearly 1 million Canadian adults to understand how the COVID-19 pandemic affected their regular care for long-term conditions like diabetes, heart failure, and depression. Researchers compared the number of doctor visits, tests, and…