Platelet injections may ease jaw arthritis pain

NCT ID NCT06573502

Completed Symptom relief Sponsor: Aliaa Babekir Ahmed Mohamed Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether injecting platelet-rich plasma (PRP) with or without platelet-rich fibrin (PRF) can reduce pain and improve jaw movement in adults with temporomandibular joint osteoarthritis. 42 participants received either a combination of PRP and PRF, PRP alone, or PRF alone. The main goal was to measure pain severity and how wide the mouth could open.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich plasma and platelet-rich fibrin injections
What this could lead to: If one of these treatments works well, it could offer a simple injection-based option to ease jaw pain and improve mouth opening for people with TMJ osteoarthritis.
What could go wrong: This is a small, completed trial with only 42 participants, so results may not apply to everyone. The treatments are not yet proven to be better than standard care, and benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS

Contacts and locations

Locations

Cairo university

Cairo, Egypt

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