New knee osteoarthritis drug shows promise in early safety trial

NCT ID NCT06263270

First seen Jan 08, 2026 · Last updated May 12, 2026 · Updated 18 times

Summary

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, with a second dose 12 weeks later. Researchers monitored side effects, pain, stiffness, and daily function over 26 weeks to see if the drug is safe and might reduce cartilage breakdown.

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Contacts and locations

Locations

  • Emeritus Research

    Camberwell, Victoria, 3124, Australia

  • Novatrials

    Kotara, New South Wales, 2289, Australia

  • University of Sunshine Coast Clinical Trials

    Sunshine Coast, Birtinya QLD, 4575, Australia

Conditions

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