ACL surgery patients studied for arthritis risk factors

NCT ID NCT00478894

Completed Knowledge-focused Sponsor: Vanderbilt University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 432 people who had ACL reconstruction surgery to see who develops osteoarthritis years later. Researchers measured knee joint space on x-rays and looked at injury details, surgical factors, and patient traits. The goal is to identify risk factors that could help prevent or delay arthritis after ACL tears.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors predict which patients are at higher risk for osteoarthritis after ACL surgery and guide better rehabilitation strategies.
What could go wrong: This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all patients or surgical techniques.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries Knee Injuries osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS RUPTURE OF ANTERIOR CRUCIATE LIGAMENT

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
The Ohio State University

Columbus, Ohio, 43221, United States
Vanderbilt University

Nashville, Tennessee, 37232, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States

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