Can a sprinkle of powder and a wash stop joint infections?
NCT ID NCT04075526
First seen Jan 09, 2026 · Last updated Jun 21, 2026 · Updated 28 times
Summary
This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. The goal was to see if these simple steps could lower the chance of a serious infection around the new joint.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston Medical Center
Boston, Massachusetts, 02118, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Centura Health
Denver, Colorado, 80210, United States
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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Cleveland Clinic Ohio
Cleveland, Ohio, 44195, United States
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Columbia
New York, New York, 10036, United States
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Eisenhower Health
Rancho Mirage, California, 92270, United States
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Hospital for Special Surgery
New York, New York, 10021, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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New England Baptist Hospital
Boston, Massachusetts, 02120, United States
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New York University Dept of Orthopedic Surgery
New York, New York, 10003, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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St. Francis Hospital
Roslyn, New York, 11576, United States
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The Orthopedic Institute of New Jersey
Sparta, New Jersey, 07871, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vancomycin powder and povidone iodine solution
What this could lead to
If successful, this could lead to a simple, low-cost way to reduce serious infections after joint replacement surgery.
What could go wrong
This is an early-phase study, so the results are not yet conclusive. The treatments may not reduce infection risk or could cause side effects like allergic reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.