Can a sprinkle of powder and a wash stop joint infections?

NCT ID NCT04075526

Completed Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. The goal was to see if these simple steps could lower the chance of a serious infection around the new joint.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vancomycin powder and povidone iodine solution
What this could lead to: If successful, this could lead to a simple, low-cost way to reduce serious infections after joint replacement surgery.
What could go wrong: This is an early-phase study, so the results are not yet conclusive. The treatments may not reduce infection risk or could cause side effects like allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease avascular necrosis osteoarthritis periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS

Contacts and locations

Locations

Boston Medical Center

Boston, Massachusetts, 02118, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Centura Health

Denver, Colorado, 80210, United States
Cleveland Clinic Florida

Weston, Florida, 33331, United States
Cleveland Clinic Ohio

Cleveland, Ohio, 44195, United States
Columbia

New York, New York, 10036, United States
Eisenhower Health

Rancho Mirage, California, 92270, United States
Hospital for Special Surgery

New York, New York, 10021, United States
Mount Sinai Hospital

New York, New York, 10029, United States
New England Baptist Hospital

Boston, Massachusetts, 02120, United States
New York University Dept of Orthopedic Surgery

New York, New York, 10003, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
St. Francis Hospital

Roslyn, New York, 11576, United States
The Orthopedic Institute of New Jersey

Sparta, New Jersey, 07871, United States

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