Knee pain relief without surgery? collagen injection shows promise
NCT ID NCT02539095
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether injecting a collagen product called CartiZol into the knee can reduce pain in people with osteoarthritis, cartilage damage, or injury-related arthritis. 200 adults with knee pain received either the collagen injection or a placebo (saline). The main goal was to measure pain levels 24 weeks after the injection using a standard pain scale. The trial is complete, and results may show whether this simple injection offers a new way to manage knee pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CartiZol (absorbable collagen injection)
- What this could lead to
- If it works, this could offer a simple injection to ease knee pain from arthritis or injury, potentially delaying or avoiding surgery.
- What could go wrong
- This is a single completed Phase 4 trial with 200 participants. The effect may be modest, and not everyone may benefit. Long-term safety and effectiveness are not yet fully known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chung-Ang University Hospital
Seoul, South Korea
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Kunkuk University Medical Center
Seoul, South Korea
-
Samsung Medical Center
Seoul, South Korea
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, South Korea
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The Catholic University of Korea, Yeouido St. Mary's Hospital
Seoul, South Korea
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