New knee gel injection aims to ease arthritis pain
NCT ID NCT05337540
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a single injection of EVI-01, a hyaluronic acid gel, in 120 people with painful knee osteoarthritis. The goal was to find the best dose that reduces pain and improves function while being safe. Participants were randomly assigned to receive one of two doses of EVI-01 or an existing treatment, and researchers tracked their symptoms over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyaluronic acid injection (EVI-01)
What this could lead to
If successful, this could provide a new option for easing knee osteoarthritis pain and stiffness with a single injection.
What could go wrong
This is a small, early dose-finding study, so results may not confirm effectiveness. The treatment only targets symptoms, not the underlying disease.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A2Z Clinical
Valinhos, São Paulo, Brazil
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Ortocity
São Paulo, Brazil