Plastic meniscus implant put to the test against standard care for knee pain

NCT ID NCT02108496

Completed Disease control Sponsor: Active Implants Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a plastic meniscus implant can outperform non-surgical treatments for people with persistent knee pain after a partial meniscus removal. Participants who had the surgery more than six months ago and are between 30 and 75 years old are randomly assigned to receive either the implant or standard care. Success is measured at two years by pain scores, the need for further surgery, and implant integrity on MRI.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a polycarbonate-urethane meniscus implant reinforced with polyethylene fibers
What this could lead to: If it works, this could offer a new treatment option for people with persistent knee pain after meniscus removal, potentially delaying or avoiding knee replacement.
What could go wrong: This is an early-stage device trial, so the implant may not provide better pain relief than standard care and carries risks like device fracture, dislocation, or the need for removal surgery.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENISCECTOMY OSTEOARTHRITIS

Contacts and locations

Locations

Advanced Orthopaedics

Richmond, Virginia, 23294, United States
Brigham and Woman's Hospital

Boston, Massachusetts, 02115, United States
Capital Region Orthopaedics

Albany, New York, 12206, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Lenox Hill Hospital

New York, New York, 10075, United States
New England Baptist Hospital

Roxbury Crossing, Massachusetts, 02120, United States
Ohio State University Medical Center

Columbus, Ohio, 43221, United States
OrthoIndy

Indianapolis, Indiana, 46143, United States
OrthoSouth

Memphis, Tennessee, 38120, United States

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