Obesity linked to higher knee implant infection risk in massive registry study

NCT ID NCT07398742

Completed Knowledge-focused Sponsor: Bispebjerg Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. They looked at how many needed revision surgery due to infection within two years, and what types of bacteria caused those infections. The goal is to help tailor preventive antibiotics and infection management for obese patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors choose better antibiotics and preventive measures for obese patients undergoing knee replacement.
What could go wrong: This is an observational study using existing records, not a controlled trial. It can show links but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthropathy juvenile polyposis syndrome Obesity osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE ARTHROPATHY PJI

Contacts and locations

Locations

Department of Orthopedic surgery and traumatology, Bispebjerg Hospital, Copenhagen, Denmark

Copenhagen NV, 2400, Denmark

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