Knee implant showdown: which one works better?

NCT ID NCT01064063

Completed Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two types of knee implants—the Vanguard Cruciate Retaining and the AGC Total Condylar—in 150 patients with knee arthritis. The goal was to see which implant provides better pain relief and function after knee replacement surgery. Patients were followed for several years to measure knee scores and success rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vanguard Cruciate Retaining knee implant and AGC total condylar knee implant
What this could lead to: If one implant proves better, it could lead to improved knee replacement outcomes for patients with arthritis.
What could go wrong: This is a completed trial with 150 participants, so results are limited to this group and may not apply to all patients. Both implants are already in use, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS RHEUMATOID ARTHRITIS TRAUMATIC ARTHRITIS

Contacts and locations

Locations

East Sussex Hospital NHS Trust

Saint Leonards-on-Sea, East Sussex, TN37 7RD, United Kingdom

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