OSTEOARTHRITIS

This study follows 299 people who received the Smith+Nephew Porous Total Knee System, a titanium knee replacement for severe arthritis. The goal is to see if the implant reduces pain, improves movement, and lasts at least two years without needing revision surgery. Participants a…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study is testing a new type of knee replacement implant that does not use cement to hold it in place. The implant, called ATTUNE Cementless Rotating Platform, is designed for people with osteoarthritis. Researchers will follow 540 patients for two years to see if their abili…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study is testing a special implant (Tapestry) that helps repair a key shoulder tendon (subscapularis) during shoulder replacement surgery. About 100 adults with shoulder arthritis or injury will be followed for 2 years to see if the tendon heals better with the implant. The …

This study follows 200 adults getting a shoulder replacement with the Zimmer Trabecular Metal Reverse Shoulder System. It aims to see how long the implant lasts and how well it relieves pain and improves movement in people with conditions like arthritis, fractures, or failed prio…

This study compares two types of total knee replacement systems: one that uses cement to hold the implant in place and one that does not. Researchers will track 300 patients with knee pain from arthritis or deformity over 5 years to see which implant leads to better pain relief, …

This study is checking how well a new hip replacement part (the HYPE stem) works and lasts over 10 years. About 180 people with hip disease from arthritis or injury will get the implant. Doctors will use X-rays and surveys to see if the implant stays firmly in place and helps red…

This study follows 194 people who received the Comprehensive Nano shoulder device to replace their shoulder joint due to arthritis, bone death, or deformity. Researchers will track how long the implant lasts and how well patients can use their shoulder over 10 years. The goal is …

This study follows 757 people who received the Persona Partial Knee system, a device used to replace only the damaged part of the knee. The goal is to see how long the implant lasts and how well patients function afterward. Participants have knee arthritis or related conditions a…

This study follows 118 people who already received a LEGION knee implant during total knee replacement surgery. Researchers will check how well the implants hold up over 10 years by measuring implant survival and patient quality of life using questionnaires. The goal is to confir…

This study follows 148 people with knee osteoarthritis who received the ANTHEM total knee replacement system. Researchers will check how well the implant holds up over 10 years by measuring survival rates and patient-reported knee function. The goal is to confirm the device is as…

This study is testing the CATALYSTEM hip system in 119 people who need a total hip replacement due to conditions like arthritis or hip damage. The goal is to see if the implant is safe and works well, focusing on how long it lasts without needing a second surgery. Participants wi…

This study follows 737 people who received a Persona knee implant to see how long it lasts and how well it works. Participants are adults aged 18-75 with severe knee pain from conditions like arthritis or bone damage. The goal is to track implant survival and knee function over t…

This pilot trial aimed to test the safety and feasibility of a single injection of a patient's own fat-derived cells (stromal vascular fraction) into the knee for post-traumatic osteoarthritis. It was designed for adults aged 18–45 with a history of knee injury. However, the stud…

This study looks at a metal plate and screw system used to fix certain types of broken upper arm bones. About 135 adults who need surgery for a fresh fracture or one that didn't heal with a cast will be followed for one year. The main goal is to see how often a second surgery is …

This study looks at how well a specific knee replacement implant works over 10 years. Researchers are checking the safety and performance of the Legion knee implant in 126 people who already received it. The goal is to see how long the implant lasts and if it helps patients with …

This study compares two ways to recover after reverse total shoulder replacement: using a smartphone app (mymobility) for home exercises versus standard in-person physical therapy. Researchers will enroll 100 adults to see if the app works just as well. The main goal is to measur…

This study looks at how well a new knee replacement system works for people with severe knee pain from arthritis or previous failed surgeries. About 255 participants will receive the implant and be followed for up to 10 years. The goal is to see if the system improves knee alignm…

This study follows 777 adults aged 18-75 who received the Persona Total Knee System to treat severe knee pain and disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers will track how long the implant lasts, how safe it is, and how well it improves pa…

This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over …

This study is following 202 people who received a special hip liner during hip replacement surgery. The goal is to see how long the liner lasts and whether it causes any problems over time. Participants are adults aged 18 to 80 with conditions like arthritis or hip fractures. The…

This study tests whether giving a single high-dose vitamin D pill to patients with low vitamin D levels before hip or knee replacement surgery can reduce complications like infection. About 200 adults with osteoarthritis and vitamin D deficiency will receive 300,000 IU of vitamin…

This study compares a new hip implant cup (Trident II) to an older version to see if it stays just as stable in the bone after surgery. Researchers will track 87 patients aged 40-75 for up to 10 years using special X-rays to measure any implant movement. The goal is to ensure the…

This study tests whether a supervised resistance exercise program can reduce the risk of osteoporosis and osteoarthritis in women aged 50-70 who have gone through menopause. Participants will do leg and core exercises twice a week for 30-40 minutes. Researchers will measure chang…

This study looks at whether putting vancomycin powder directly into the joint during hip or knee replacement surgery can prevent infections better than standard IV antibiotics alone. About 1,800 adults having primary or revision joint replacement are being followed for two years.…

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This pilot study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. The treatment blocks abnormal blood vessels in the knee to reduce pain and swelling. Twenty participants will be randomly assigned to either receive the …

This study looks at whether a treatment called pulsed radiofrequency (PRF) applied to a key shoulder nerve can help people with long-lasting shoulder pain that hasn't improved with standard treatments like painkillers or physical therapy. The study involves 60 adults with chronic…

This study tests a new procedure called genicular artery embolization using SakuraBead, a dissolvable bead that blocks small blood vessels in the knee to reduce pain. It involves 89 adults aged 40-79 with moderate to severe knee osteoarthritis that hasn't improved with standard t…

This study planned to test an injection of doxycycline into the knee area to reduce chronic pain in people with osteoarthritis who cannot have surgery. The trial was withdrawn before enrolling any participants, so no data was collected. The goal was to see if the procedure could …

This study follows 40 adults aged 55+ with osteoarthritis who are getting low-dose radiation as part of their usual care. Researchers will track pain, function, and quality of life for up to a year to see if the treatment helps. The goal is to understand how well this approach wo…

This study tests whether giving patients a pain education booklet and video before knee or hip replacement surgery helps them feel less anxious and have less pain afterward. About 70 adults scheduled for elective joint replacement will be randomly assigned to receive the educatio…

This study compares a newer surgical approach that spares the rotator cuff to the traditional method for total shoulder replacement in 108 adults with arthritis. The goal is to see which approach leads to better shoulder function and recovery. Participants will be followed for at…

This study tested whether shortwave diathermy, a treatment that uses heat deep in the tissue, can help people with hand osteoarthritis. 36 adults aged 35-75 with hand osteoarthritis received either real or placebo treatment. Researchers measured pain, grip strength, and daily han…

This study tested whether two types of gentle brain stimulation (tDCS and TUS) can reduce pain and improve daily function in people with chronic knee osteoarthritis. 64 adults with persistent knee pain received either real or sham stimulation. Researchers measured changes in pain…

This study tests whether turmeric extract capsules can lower inflammation and pain in people with knee osteoarthritis. 72 adults will take either turmeric or a placebo daily for 3 weeks. Researchers will measure pain and inflammatory markers in the blood.

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …

This study looks at two different knee replacement parts to see how much they move after surgery. Researchers will track 60 people with osteoarthritis over two years using special X-rays. The goal is to find out which type stays more stable in the bone.

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study involves 100 people with knee osteoarthritis to compare different ways of measuring knee function, including patient questionnaires and physical tests like walking and standing. The goal is to understand how subjective reports and objective performance relate to each o…

This study is building a large collection of blood samples from 3,000 people with rheumatoid arthritis. Researchers will use these samples to look for biomarkers that could help predict disease activity or treatment side effects. Participants must already be in a registry and sta…

This study collects fluid from the joints of 149 adults having knee, hip, or shoulder surgery. Researchers will analyze the fluid for molecules and genetic clues that could help detect osteoarthritis earlier or predict how the disease will progress. The goal is to build a biobank…

This study looks at how well a new hip replacement stem (Insignia) fits and stays in place over time. Researchers will review X-rays from 100 adults getting a first-time hip replacement to check for any signs of loosening. The goal is to see if the stem is safe and effective for …

This study compares two types of hip replacement implants to see if one raises metal levels in the blood more than the other. Fifty-two adults getting a hip replacement will be randomly assigned to receive either a standard implant or a newer 'dual mobility' design. Researchers w…

This study is building a large national registry of 30,000 people having hip or knee replacement surgery. Researchers will collect information on pain, physical function, and any complications before and after surgery. The goal is to learn what works best in real-world practice a…

This study looks at why people with bone cancer (skeletal sarcoma) get more infections after joint replacement surgery than those with arthritis. Researchers will collect tissue and blood samples from 40 patients to compare immune and bacterial factors. The goal is to understand …

This study is following 230 adults who received a G7 hip replacement system to see how long the implant lasts and how well it works. Participants have hip problems like arthritis or bone death. The study does not test a new treatment but simply watches and records outcomes over t…

This study follows 280 adults aged 18–75 who received a new type of hip implant (MonoCer cup) during a total hip replacement. Researchers will check how long the implant lasts without needing replacement, and measure pain, function, and satisfaction over 2, 5, and 10 years. The g…