OSTEOARTHRITIS

This study looked at how well a metal plate (A.L.P.S. Proximal Humerus Plating System) works for fixing broken upper arm bones. It included 135 adults who needed surgery for a fresh fracture. The main goal was to see how many people needed another surgery within a year due to pro…

This study looks at how well a new knee replacement system works in people with severe knee pain from arthritis or after a previous knee replacement failed. About 255 adults will get the new implant and be followed for up to 10 years. The goal is to see if the system improves kne…

This study looks at how well a knee replacement system works for people with arthritis or other knee damage. About 299 patients will receive the implant to see if it reduces pain, improves movement, and lasts a long time. The goal is to show that most patients do well after surge…

This study follows 200 people who received a specific shoulder replacement system to see how long it lasts and how well it works. Participants have conditions like arthritis, fractures, or rotator cuff problems. Researchers measure pain and function using standard shoulder assess…

This study is checking how safe and well a new shoulder implant, the Sidus Stem-Free Shoulder, works for people with severe shoulder arthritis. About 152 people who need a shoulder replacement are taking part. The study looks at pain, movement, and quality of life after surgery.

This study compares two types of total knee replacements: one that uses bone cement to hold the implant in place and one that does not. The goal is to see which approach provides better pain relief, function, and implant survival over time. About 300 adults with knee arthritis or…

This study looks at whether giving a single high dose of vitamin D before hip or knee replacement surgery can lower the chance of complications, like infection, in patients who have low vitamin D levels. About 200 adults with low vitamin D will take part. The goal is to see if co…

This study follows 737 people who received the Persona knee implant to see how well it works over time. Participants had severe knee pain from conditions like arthritis or injury. The goal is to measure implant survival and improve knee function.

This study is testing a new knee implant called Persona Ti-Nidium in 240 adults who need a total knee replacement due to arthritis or other knee problems. The goal is to see if the implant is safe and helps people move better and feel less pain. Participants will have surgery and…

This early-phase trial aimed to test the safety and feasibility of a single injection of a patient's own fat-derived cells (stromal vascular fraction) for knee osteoarthritis caused by a past injury. It planned to enroll adults aged 18-45 with moderate knee arthritis and pain. Ho…

This study looks at how well a new hip replacement system, called CATALYSTEM, works in 119 people who need a total hip replacement. The main goal is to check if the implant stays in place without problems two years after surgery. The study includes patients with conditions like a…

This study follows 777 people aged 18 to 75 who received a Persona knee implant to treat severe knee pain and disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers are checking how long the implant lasts, how safe it is, and how well it improves pain…

This study looks at whether different types of resistance exercise (like lifting weights) can help prevent osteoporosis (weak bones) and osteoarthritis (joint disease) in women aged 50 to 70 who have gone through menopause. Researchers will measure changes in bone density, muscle…

This study compares a newer surgical method for total shoulder replacement that spares the rotator cuff to the traditional approach. About 108 adults with shoulder arthritis will be randomly assigned to one of the two techniques. Researchers will track shoulder function, strength…

This study tests whether turmeric capsules can lower pain and inflammation in adults with knee osteoarthritis. 72 participants will take either turmeric or a placebo daily for 3 weeks. Researchers will measure changes in blood markers of inflammation and pain levels to see if tur…

This study looks at two common treatments for people who have both a torn meniscus and knee arthritis: surgery to remove part of the torn cartilage, or physical therapy without surgery. Researchers want to see which approach works better for improving knee function and reducing p…

This study tests whether gloves with built-in semiconductors can reduce pain and improve hand function in people with hand osteoarthritis. About 140 adults aged 40 to 75 with confirmed hand OA will wear the gloves and report their pain levels and hand ability. The goal is to see …

This study tested whether shortwave diathermy, a type of heat therapy, can reduce pain and improve grip strength in people with hand osteoarthritis. 36 adults with hand osteoarthritis received either real or placebo shortwave treatment. Researchers measured pain levels, hand func…

This study looks at how well a new cementless knee replacement works for people with osteoarthritis. About 540 adults aged 22 to 80 will get the implant and report their pain and daily function over two years. The goal is to see if the implant improves movement and quality of lif…

This study tests whether gentle electrical and ultrasound brain stimulation can reduce pain and improve daily function in people with knee osteoarthritis. About 64 adults with chronic knee pain will receive either real or fake (sham) stimulation to see if it lowers pain scores. T…

This study aimed to test a new pain management procedure for people with chronic knee pain who cannot have surgery. The treatment involved injecting doxycycline into certain blood vessels around the knee to reduce pain. However, the study was withdrawn before any participants wer…

This study follows 40 adults aged 55 and older with osteoarthritis who are receiving low-dose radiation therapy as part of their usual care. Researchers will track changes in pain, physical function, and quality of life over one year to see if this treatment helps ease symptoms. …

This study tests a new procedure called genicular artery embolization using SakuraBead, a dissolvable bead that blocks small blood vessels in the knee to reduce pain. It includes 89 adults aged 40-79 with moderate to severe knee osteoarthritis that hasn't improved with standard t…

This study collects fluid from the joints of 149 adults undergoing surgery for osteoarthritis or pre-arthritis. Researchers will analyze the fluid for biomarkers and genetic clues that could help detect the disease earlier and guide better treatments. The goal is to understand ho…

This study follows 194 people who received a specific shoulder replacement device to see how well it works over time. It includes patients with arthritis, bone death, or previous failed treatments. The goal is to collect safety and performance data for up to 10 years after surger…

This study looks at whether an AI chatbot can help people with hip or knee osteoarthritis feel less anxious and more confident when making decisions about their treatment. About 100 adults will chat with the AI before their doctor visit. The goal is to see if the chatbot reduces …

This study looks at two different designs for the bottom part of a knee replacement: one made entirely of plastic and one with a metal backing. The goal is to see how much each design moves inside the bone over two years using a special X-ray technique. Sixty people with knee ost…

This study follows 230 adults getting a hip replacement with the G7 Acetabular System to see how long the implant lasts. Participants have hip problems like arthritis or bone death. The study does not test a new treatment but collects information on implant survival and patient-r…

This study follows 757 people who received a Persona Partial Knee System to treat knee problems like arthritis or injury. Researchers are collecting patient-reported outcomes, such as knee function and quality of life, to see how well the implant performs over time. The goal is t…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study looks at how knee osteoarthritis (KOA) impacts daily life by using both patient surveys and physical tests like walking and stair climbing. Researchers will enroll 100 adults aged 45-75 with moderate knee arthritis. The goal is to better understand function from both t…

This study is creating a national registry to track the long-term results of hip and knee replacement surgeries. It will follow 30,000 patients from diverse backgrounds to understand what leads to better pain relief, function, and fewer complications after surgery. The goal is to…